Differences in human antioxidized LDL autoantibodies in patients with stable and unstable angina

dc.creatorFernandes, JL
dc.creatorOrford, JL
dc.creatorGarcia, C
dc.creatorCoelho, OR
dc.creatorGidlund, M
dc.creatorBlotta, MHSL
dc.date2004
dc.dateDEC
dc.date2014-11-15T13:13:43Z
dc.date2015-11-26T17:19:59Z
dc.date2014-11-15T13:13:43Z
dc.date2015-11-26T17:19:59Z
dc.date.accessioned2018-03-29T00:07:36Z
dc.date.available2018-03-29T00:07:36Z
dc.identifierJournal Of Autoimmunity. Academic Press Ltd Elsevier Science Ltd, v. 23, n. 4, n. 345, n. 352, 2004.
dc.identifier0896-8411
dc.identifierWOS:000225753700006
dc.identifier10.1016/j.jaut.2004.08.004
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61759
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61759
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61759
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283026
dc.descriptionBackground: Autoantibodies to oxidized LDL (anti-oxLDL) have been found in the serum of patients with coronary artery disease (CAD). This study was designed to compare the differences in anti-oxLDL titers and isotypes in unstable and stable angina patients and to correlate these results with known markers of active inflammation in CAD. Methods: Thirty patients from a tertiary referral general hospital with documented CAD were studied. Anti-oxLDL IgG titers and its isotypes, high sensitivity C-reactive protein (hsCRP) and serum amyloid A (SAA) were measured. Results: The anti-oxLDL IgG titer was lower (p = 0.03) in the unstable angina group compared to the stable angina patients (0.084 +/- 0.102 OD versus 0.195 +/- 0.149 OD, respectively). The predominant IgG isotype in both groups was IgG2. IgG4 was significantly higher (0.270 +/- 0.146 OD, p = 0.04) in the unstable angina group versus patients with stable angina (0.198 +/- 0.019 OD). There was a significant inverse correlation between anti-oxLDL and hsCRP and SAA in this sample population (R 0.37, p < 0.05 and R = 0.36, p < 0.05, respectively). Conclusion: Patients with unstable angina have lower levels of anti-oxLDL IgG in the acute setting of CAD. Plaque instabilization does not seem to acutely modify the isotype subsets of anti-oxLDL IgG in these patients. (C) 2004 Elsevier Ltd. All rights reserved.
dc.description23
dc.description4
dc.description345
dc.description352
dc.languageen
dc.publisherAcademic Press Ltd Elsevier Science Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationJournal Of Autoimmunity
dc.relationJ. Autoimmun.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectatherosclerosis
dc.subjectautoantibody
dc.subjectcoronary artery disease
dc.subjectimmune system
dc.subjectinflammation
dc.subjectLow-density-lipoprotein
dc.subjectCoronary-artery-disease
dc.subjectMalondialdehyde-modified Ldl
dc.subjectOxidized Ldl
dc.subjectAtherosclerotic Lesions
dc.subjectMyocardial-infarction
dc.subjectImmune-complexes
dc.subjectAutoimmune-response
dc.subjectMacrophage Uptake
dc.subjectOxidative Stress
dc.titleDifferences in human antioxidized LDL autoantibodies in patients with stable and unstable angina
dc.typeArtículos de revistas


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