Regulation of human alpha-globin gene expression and alpha-thalassemia

dc.creatorRibeiro, DM
dc.creatorSonati, MF
dc.date2008
dc.date2014-11-15T12:30:50Z
dc.date2015-11-26T17:19:59Z
dc.date2014-11-15T12:30:50Z
dc.date2015-11-26T17:19:59Z
dc.date.accessioned2018-03-29T00:07:36Z
dc.date.available2018-03-29T00:07:36Z
dc.identifierGenetics And Molecular Research. Funpec-editora, v. 7, n. 4, n. 1045, n. 1053, 2008.
dc.identifier1676-5680
dc.identifierWOS:000260227200007
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80046
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/80046
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80046
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283025
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionHemoglobin and globin genes are important models for studying protein and gene structure, function and regulation. We reviewed the main aspects of regulation of human alpha-globin synthesis, encoded by two adjacent genes (alpha 2 and alpha 1) clustered on chromosome 16. Their expression is controlled mainly by a regulatory element located 40 kb upstream on the same chromosome, the alpha-major regulatory element, whose activity is restricted to a core fragment of 350 bp, within which several regulatory protein binding sites have been found. Natural deletions involving alpha-major regulatory element constitute a particular category of alpha-thalassemia determinants in which the alpha-globin genes are physically intact but functionally inactive.
dc.description7
dc.description4
dc.description1045
dc.description1053
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [02/13801-7, 03/07412-0]
dc.descriptionCNPq [475481/2006-2]
dc.languageen
dc.publisherFunpec-editora
dc.publisherRibeirao Preto
dc.publisherBrasil
dc.relationGenetics And Molecular Research
dc.relationGenet. Mol. Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectHemoglobin
dc.subjectGlobin genes
dc.subjectHS-40
dc.subjectThalassemia
dc.subjectGene expression
dc.subjectAlpha-major regulatory element
dc.subjectActive Chromatin Hub
dc.subjectDe-novo Deletion
dc.subjectElement Hs-40
dc.subjectTransgenic Mice
dc.subjectHypersensitive Sites
dc.subjectFar Upstream
dc.subjectZeta-globin
dc.subjectLocus
dc.subjectCluster
dc.subjectRegion
dc.titleRegulation of human alpha-globin gene expression and alpha-thalassemia
dc.typeArtículos de revistas


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