Regulation of the GATA3 promoter by human T-cell lymphotropic virus type I tax protein

dc.creatorGilli, SCO
dc.creatorSalles, TSI
dc.creatorSaad, STA
dc.date2004
dc.dateDEC 15
dc.date2014-11-15T12:11:01Z
dc.date2015-11-26T17:19:54Z
dc.date2014-11-15T12:11:01Z
dc.date2015-11-26T17:19:54Z
dc.date.accessioned2018-03-29T00:07:33Z
dc.date.available2018-03-29T00:07:33Z
dc.identifierJournal Of Cellular Biochemistry. Wiley-liss, v. 93, n. 6, n. 1178, n. 1187, 2004.
dc.identifier0730-2312
dc.identifierWOS:000225416700010
dc.identifier10.1002/jcb.20290
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80067
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/80067
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80067
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283008
dc.descriptionThe Human T-cell leukemia virus type 1 (HTLV-1) non-structural protein Tax plays a crucial role incellular transformation. It activates the transcription factors of various cellular genes and interacts with cellular proteins. There is limited data available on the interaction between specific T-cell transcription factor GATA3 and Tax. Implications for the significance of GATA3 in T-cell development and function, T helper2 (Th2) differentiation, and a role of GATA3 during the immune response have been reported. To determine the effect of the Tax protein on GATA3 gene expression, we investigated the interaction between this protein and the GATA3 promoter and repressor regions. Results demonstrated an interaction between Tax and the GATA3promoter via the transcription factor Sp1 and a role for Tax in the negative regulation of GATA3 expression, through its interaction with the repressor ZEB. This interaction may be involved in the pathophysiology of adult T-cell leukemia/lymphoma (ATL) and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). (C) 2004 Wiley-Liss, Inc.
dc.description93
dc.description6
dc.description1178
dc.description1187
dc.languageen
dc.publisherWiley-liss
dc.publisherHoboken
dc.publisherEUA
dc.relationJournal Of Cellular Biochemistry
dc.relationJ. Cell. Biochem.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectGATA3 activity
dc.subjecttax
dc.subjectviral transactivator
dc.subjectSp1
dc.subjectZEB
dc.subjectNf-kappa-b
dc.subjectTranscription Factor Gata-3
dc.subjectLeukemia-virus
dc.subjectExpression
dc.subjectGene
dc.subjectHtlv-1
dc.subjectActivation
dc.subjectSequence
dc.subjectBinding
dc.subjectAmplification
dc.titleRegulation of the GATA3 promoter by human T-cell lymphotropic virus type I tax protein
dc.typeArtículos de revistas


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