Antioxidative action of methanolic extract and buthanolic fraction of Vochysia tucanorum Mart. in the gastroprotection

dc.creatorGomes, RD
dc.creatorBonamin, F
dc.creatorDarin, DD
dc.creatorSeito, LN
dc.creatorDi Stasi, LC
dc.creatorDokkedal, AL
dc.creatorVilegas, W
dc.creatorBrito, ARMS
dc.creatorHiruma-Lima, CA
dc.date2009
dc.date10959
dc.date2014-11-15T11:22:55Z
dc.date2015-11-26T17:19:49Z
dc.date2014-11-15T11:22:55Z
dc.date2015-11-26T17:19:49Z
dc.date.accessioned2018-03-29T00:07:29Z
dc.date.available2018-03-29T00:07:29Z
dc.identifierJournal Of Ethnopharmacology. Elsevier Ireland Ltd, v. 121, n. 3, n. 466, n. 471, 2009.
dc.identifier0378-8741
dc.identifierWOS:000263393200017
dc.identifier10.1016/j.jep.2008.11.013
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77941
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77941
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77941
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282993
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAim of the study: Vochysia tucanorum is an important medicinal plant used in the Cerrado of Brazil against gastric disorders and this study reveals the pharmacological action of this traditional medicine use. Materials and methods: The methanolic extract (E-MeOH) and buthanolic fraction (Fr-Bu) obtained from V. tucanorum were challenged by different necrotizing agents in rodents. NO-synthase inhibitor (L-NAME) and SH blocker (NEM) were used to evaluate the participation of cytoprotective factors in E-MeOH and Fr-Bu gastroprotection. Antiulcerogenic action of V. tucanorum was evaluated in rats and mice at doses 250, 500 or 1000 mg/kg (E-MeOH) and 37.5, 75 or 150 mg/kg (Fr-Bu). Results: Both E-MeOH and Fr-Bu present elevated gastroprotective action in all in vivo experimental models, without signs of acute toxicity. The mechanisms involved in the gastroprotective action of E-MeOH and Fr-Bu are related to the antioxidant activity and protection to gastric mucosa NO levels. Phytochemical investigations of Fr-Bu identified different pentacyclic triterpenoids such as betulinic acid, erythrodiol, epi-betulinic acid and mixtures of ursolic acid and oleanolic acid derivatives as the major constituents. The presence of such triterpenoids in Fr-Bu is probably related to the potent gastro protective action of this medicinal plant species. Conclusion: Effectiveness in gastro protection and the absence of acute toxicity indicate this species as a promising herbal drug that is in accordance with ethnopharmacological use against gastric disorders. Published by Elsevier Ireland Ltd
dc.description121
dc.description3
dc.description466
dc.description471
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [02105503-6]
dc.descriptionCNPq [ARMS13]
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationJournal Of Ethnopharmacology
dc.relationJ. Ethnopharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectVochysia tucanorum
dc.subjectVochysiaceae
dc.subjectGastric ulcer
dc.subjectTriterpenoids
dc.subjectPylorus Ligation
dc.subjectOleanolic Acid
dc.subjectBetulinic Acid
dc.subjectNitric-oxide
dc.subjectTriterpenoids
dc.subjectRats
dc.subjectLesions
dc.subjectUlcer
dc.subjectProstaglandins
dc.subjectDerivatives
dc.titleAntioxidative action of methanolic extract and buthanolic fraction of Vochysia tucanorum Mart. in the gastroprotection
dc.typeArtículos de revistas


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