Antiproliferation of human prostate cancer cells by ethanolic extracts of Brazilian propolis and its botanical origin

dc.creatorLi, HZ
dc.creatorKapur, A
dc.creatorYang, JX
dc.creatorSrivastava, S
dc.creatorMcLeod, DG
dc.creatorParedes-Guzman, JF
dc.creatorDaugsch, A
dc.creatorPark, YK
dc.creatorRhim, JS
dc.date2007
dc.dateSEP
dc.date2014-11-15T11:21:26Z
dc.date2015-11-26T17:19:47Z
dc.date2014-11-15T11:21:26Z
dc.date2015-11-26T17:19:47Z
dc.date.accessioned2018-03-29T00:07:26Z
dc.date.available2018-03-29T00:07:26Z
dc.identifierInternational Journal Of Oncology. Professor D A Spandidos, v. 31, n. 3, n. 601, n. 606, 2007.
dc.identifier1019-6439
dc.identifierWOS:000248695800016
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77949
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77949
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77949
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282983
dc.descriptionPropolis is a resinous substance collected by bees (Apis mellifera) from various tree buds which they then use to coat hive parts and to seal cracks and crevices in the hive. Propolis, a known ancient folk medicine, has been extensively used in diet to improve health and to prevent disease. In the present study, we have evaluated the effects of ethanolic extracts of Brazilian propolis group 12 and bud resins of botanical origin (B. dracunculifolia), and propolis group 3 on proliferation of metastasis (DU145 and PC-3) and primary malignant tumor (RC58T/h/SA#4)-derived human prostate cancer cells. The strongest inhibition was observed in propolis group 3 (sample #3) extracts whereas moderate growth inhibition was observed in human prostate epithelial cells. In the RC58T/h/SA#4 cells, resins of botanical origin of propolis group 12 (sample #1) and propolis group 12 (sample #2) induced growth inhibition that was associated with S phase arrest whereas propolis group 3 (sample #3) induced growth inhibition that was associated with G2 arrest. The mechanisms of cell cycle effects of propolis were investigated. The resins of botanical origin of propolis group 12 and propolis group 12 showed similar inhibition of cyclin D1, CDK4 and cyclin B1 expression. Propolis group 3 showed higher induction of p21 expression but no inhibition of cyclin D1, CDK4 and cyclin B1 expression. The results obtained here demonstrate that the Brazilian propolis extracts have significant inhibitory effect on proliferation of human prostate cancer cells. Inhibition was achieved through regulation of protein expression of cyclin D1, B1 and cyclin dependent kinase (CDK) as well as p21. Our results indicate that the Brazilian propolis extracts show promise as chemotherapeutic agents as well as preventive agents against prostate cancer.
dc.descriptionO TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE FEVEREIRO DE 2015.
dc.description31
dc.description3
dc.description601
dc.description606
dc.languageen
dc.publisherProfessor D A Spandidos
dc.publisherAthens
dc.publisherGrécia
dc.relationInternational Journal Of Oncology
dc.relationInt. J. Oncol.
dc.rightsembargo
dc.sourceWeb of Science
dc.subjectmalignant human prostate cancer cells
dc.subjectantiproliferation
dc.subjectBrazilian propolis
dc.subjectcell cycle
dc.subjectBiological-properties
dc.subjectChemical-composition
dc.subjectArtepillin-c
dc.subjectCyclin D1
dc.subjectApoptosis
dc.subjectToxicity
dc.titleAntiproliferation of human prostate cancer cells by ethanolic extracts of Brazilian propolis and its botanical origin
dc.typeArtículos de revistas


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