Adrenocortical tumors in Brazilian children - Immunohistochemical markers and prognostic factors

dc.creatorSbragia, L
dc.creatorOliveira, AG
dc.creatorVassallo, J
dc.creatorPinto, GA
dc.creatorGuerra, G
dc.creatorBustorff-Silva, J
dc.date2005
dc.dateSEP
dc.date2014-11-15T10:27:45Z
dc.date2015-11-26T17:19:35Z
dc.date2014-11-15T10:27:45Z
dc.date2015-11-26T17:19:35Z
dc.date.accessioned2018-03-29T00:07:14Z
dc.date.available2018-03-29T00:07:14Z
dc.identifierArchives Of Pathology & Laboratory Medicine. College Amer Pathologists, v. 129, n. 9, n. 1127, n. 1131, 2005.
dc.identifier0003-9985
dc.identifierWOS:000231517800009
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76812
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/76812
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76812
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282933
dc.descriptionContext.-The behavior of adrenocortical tumors (ACTs) is usually difficult to establish in childhood, and the role of immunomarkers in predicting outcome has not yet been elucidated. Objective.-To investigate the relationship between clinical pathologic, and immunohistochemical findings and prognosis in a series of children with ACTs. Patients and Methods.-Clinical data were evaluated retrospectively in 33 children with ACTs, including age at diagnosis, sex, time between first symptoms and diagnosis, clinical signs and symptoms, tumor position, and followup. Histologic sections were reviewed, each tumor was classified, and staging was performed according to previously published criteria. Immunohistochemical analysis of p53, Ki-67, c-Erb-132, and Bcl-2 was performed according to previously published techniques. Results.-Sixty-four percent (n = 21) of the patients were female, and the age at diagnosis in the cohort ranged from 2 to 96 months. Virilization alone affected 70% (n = 23) of the patients, and 18 patients had stage 1 disease, 9 had stage 2 disease, and 3 each had stage 3 and stage 4 disease. Female sex and stage I and stage 2 disease were associated with good outcome. None of the histopathologic criteria evaluated correctly predicted outcome. Only tumors with a volume exceeding 200 mL were associated with malignant behavior. Because only a small number of tumors expressed the antigens, results of these immunohistochemical tests were considered inconclusive. Conclusion.-In this sample of pediatric ACTs, the clinical and surgical parameters are the most important prognostic factors, while the immunohistochemical markers evaluated were not predictive of outcome.
dc.description129
dc.description9
dc.description1127
dc.description1131
dc.languageen
dc.publisherCollege Amer Pathologists
dc.publisherNorthfield
dc.publisherEUA
dc.relationArchives Of Pathology & Laboratory Medicine
dc.relationArch. Pathol. Lab. Med.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectAdrenal-cortical Carcinoma
dc.subjectBcl-2 Expression
dc.subjectP53 Expression
dc.subjectCancer
dc.subjectNeoplasms
dc.subjectGene
dc.subjectMutations
dc.subjectSurvival
dc.subjectProtein
dc.subjectTissue
dc.titleAdrenocortical tumors in Brazilian children - Immunohistochemical markers and prognostic factors
dc.typeArtículos de revistas


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