Artículos de revistas
Diastereo- and enantioselective synthesis of a conagenin skeletal amide moiety
Registro en:
Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 45, n. 18, n. 3579, n. 3582, 2004.
0040-4039
WOS:000221022500009
10.1016/j.tetlet.2004.03.062
Autor
Augusto, J
Rodrigues, R
Moran, PJS
Milagre, CDF
Ursini, CV
Institución
Resumen
A synthetic study was carried out to obtain epimers of a protected 2,4-dihydroxy-3-methylpentanoic ester 9, which is a central building block of the immunomodulator (+)-conagenin 1. The configuration of the three contiguous stereogenic centers was determined by NMR measurements and comparison with the stereogenic centers of lactone 10. (C) 2004 Elsevier Ltd. All rights reserved. 45 18 3579 3582