Diastereo- and enantioselective synthesis of a conagenin skeletal amide moiety

Augusto, J; Rodrigues, R; Moran, PJS; Milagre, CDF; Ursini, CV

Artículos de revistas

Registration in:

Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 45, n. 18, n. 3579, n. 3582, 2004.

0040-4039

WOS:000221022500009

10.1016/j.tetlet.2004.03.062

http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61688

http://www.repositorio.unicamp.br/handle/REPOSIP/61688

http://repositorio.unicamp.br/jspui/handle/REPOSIP/61688

http://repositorioslatinoamericanos.uchile.cl/handle/2250/1282846

Author

Augusto, J

Rodrigues, R

Moran, PJS

Milagre, CDF

Ursini, CV

Institutions

Universidade Estadual de Campinas (Brasil)

Abstract

A synthetic study was carried out to obtain epimers of a protected 2,4-dihydroxy-3-methylpentanoic ester 9, which is a central building block of the immunomodulator (+)-conagenin 1. The configuration of the three contiguous stereogenic centers was determined by NMR measurements and comparison with the stereogenic centers of lactone 10. (C) 2004 Elsevier Ltd. All rights reserved.

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