Precipitation of clavulanic acid from fermentation broth with potassium 2-ethyl hexanoate salt

dc.creatorHirata, DB
dc.creatorOliveira, JHHL
dc.creatorLeao, KV
dc.creatorRodrigues, MI
dc.creatorFerreira, AG
dc.creatorGiulietti, M
dc.creatorBarboza, M
dc.creatorHokka, CO
dc.date2009
dc.dateMAY 7
dc.date2014-11-15T00:16:53Z
dc.date2015-11-26T17:17:57Z
dc.date2014-11-15T00:16:53Z
dc.date2015-11-26T17:17:57Z
dc.date.accessioned2018-03-29T00:05:47Z
dc.date.available2018-03-29T00:05:47Z
dc.identifierSeparation And Purification Technology. Elsevier Science Bv, v. 66, n. 3, n. 598, n. 605, 2009.
dc.identifier1383-5866
dc.identifierWOS:000266059200024
dc.identifier10.1016/j.seppur.2009.01.010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81196
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/81196
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81196
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282569
dc.descriptionThis paper describes a direct precipitation reaction of clavulanic acid (CA) using potassium 2-ethyl hexanoate salt. Clavulanic acid is an important molecule produced by the pharmaceutical industry to overcome problems relating to bacterial resistance to antibiotics. However, precipitation of this organic compound has been little studied and, unlike inorganic compounds, its isolation and precipitation usually involve a complex and meticulous process. The purpose of this work was to improve the purification process and increase the yield of CA from fermented broth by examining the influence of the combined concentrations of clavulanic acid (in organic solvent) and potassium 2-ethyl hexanoate on the potassium clavulanate precipitation reaction. Clavulanic acid was extracted at temperatures below 20 degrees C and preferably close to 15 degrees C in the water-immiscible organic solvent ethyl acetate. The drying step was performed with a suitable desiccant to produce an insoluble salt of potassium clavulanate. The resulting precipitate was crystalline and stable, a finding that was confirmed by an NMR (1)H analysis. (C) 2009 Elsevier B.V. All rights reserved.
dc.description66
dc.description3
dc.description598
dc.description605
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationSeparation And Purification Technology
dc.relationSep. Purif. Technol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectClavulanic acid
dc.subjectPotassium clavulanate
dc.subjectPrecipitation
dc.subjectPotassium 2-ethyl hexanoate
dc.subjectPurification
dc.subjectChromatography
dc.subjectAdsorption
dc.subjectExchange
dc.subjectSystems
dc.titlePrecipitation of clavulanic acid from fermentation broth with potassium 2-ethyl hexanoate salt
dc.typeArtículos de revistas


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