Direct determination of paracetamol in powdered pharmaceutical samples by fluorescence spectroscopy

dc.creatorMoreira, AB
dc.creatorOliveira, HPM
dc.creatorAtvars, TDZ
dc.creatorDias, ILT
dc.creatorNeto, GO
dc.creatorZagatto, EAG
dc.creatorKubota, LT
dc.date2005
dc.dateMAY 10
dc.date2014-11-20T06:22:12Z
dc.date2015-11-26T17:16:18Z
dc.date2014-11-20T06:22:12Z
dc.date2015-11-26T17:16:18Z
dc.date.accessioned2018-03-29T00:04:28Z
dc.date.available2018-03-29T00:04:28Z
dc.identifierAnalytica Chimica Acta. Elsevier Science Bv, v. 539, n. 41671, n. 257, n. 261, 2005.
dc.identifier0003-2670
dc.identifierWOS:000229175100036
dc.identifier10.1016/j.aca.2005.03.012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62600
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/62600
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62600
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282249
dc.descriptionThe native fluorescence of paracetamol (PA) in the solid state is demonstrated, allowing the development of a rapid, simple and rugged method for direct analysis of pharmaceutical formulations. It is easily adaptable to any spectrofluorimeter, and no chemical treatment of the sample is needed. The fluorescence measurements (λ(ex) = 333 nm; λ(em) = 382 nm) are performed directly on the powdered sample, the active substance being diluted in lactose, maize starch, poly(vinylpyrrolidone), tale and stearic acid. The influence of the ingredients of PA formulations is discussed. Fluorescence intensity is linearly dependent on PA concentration within the 100-400 mg g(-1) range. The analytical frequency is 200 h(-1). Detection and quantification limits were estimated within the 13.0-16.7 and 43.1-55.7 mg g(-1) ranges for samples with different ingredient proportions. The method was applied to pharmaceutical formulations and the relative standard deviation of results was < 2.7% (n = 20) for all tested ingredient proportions. Results were compared with those obtained by a method recommended by the British Pharmacopoeia and no statistical difference between methods was found at the 95% confidence level. © 2005 Elsevier B.V. All rights reserved.
dc.description539
dc.description41671
dc.description257
dc.description261
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationAnalytica Chimica Acta
dc.relationAnal. Chim. Acta
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectsolid-phase analysis
dc.subjectfluorescence spectroscopy
dc.subjectparacetamol
dc.subjectacetaminophen
dc.subjectInjection Spectrophotometric Determination
dc.subjectInfrared Transmittance Spectroscopy
dc.subjectFlow-injection
dc.subjectAcetylsalicylic-acid
dc.subjectDrug Formulations
dc.subjectIntact Tablets
dc.subjectAcetaminophen
dc.subjectQuantification
dc.subjectHplc
dc.subjectChlorpheniramine
dc.titleDirect determination of paracetamol in powdered pharmaceutical samples by fluorescence spectroscopy
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución