Restored insulin inhibition on insulin secretion in nondiabetic severely obese patients after weight loss induced by bariatric surgery

dc.creatorPereira, JA
dc.creatorClaro, BM
dc.creatorPareja, JC
dc.creatorChaim, EA
dc.creatorAstiarraga, BD
dc.creatorSaad, MJA
dc.creatorMuscelli, E
dc.date2003
dc.dateAPR
dc.date2014-11-20T06:22:54Z
dc.date2015-11-26T17:16:17Z
dc.date2014-11-20T06:22:54Z
dc.date2015-11-26T17:16:17Z
dc.date.accessioned2018-03-29T00:04:28Z
dc.date.available2018-03-29T00:04:28Z
dc.identifierInternational Journal Of Obesity. Nature Publishing Group, v. 27, n. 4, n. 463, n. 468, 2003.
dc.identifier0307-0565
dc.identifierWOS:000182095600007
dc.identifier10.1038/sj.ijo.0802269
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71065
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71065
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71065
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282246
dc.descriptionOBJECTIVE: To examine the impact of important weight loss on insulin inhibition of its own secretion during experimentally induced hyperinsulinemia under euglycemic conditions. DESIGN: Longitudinal, clinical intervention study-bariatric surgery (vertical banded gastroplasty-gastric bypass-Capella technique), re-evaluation after 4 and 14 months. SUBJECTS: Nine obese patients class III (BIVII =54.6+/-2.6kg /m(2)) and nine lean subjects (BIVII = 22.7+/-0.7 kg/m(2)). MEASUREMENTS: Euglycemic hyperinsulinemic clamp (insulin infusion: 40 mU/min m(2)), C-peptide plasma levels, electrical bicimpedance methodology, and oral glucose tolerance test (OGTT). RESULTS: BIVII was reduced in the follow-up: 44.5+/-2.2 and 33.9+/-1.5 kg/m(2) at 4 and 14 months. insulin-induced glucose uptake was markedly reduced in obese patients (19.5+/-1.9 mumol/min kg FFM) and improved with weight loss, but in the third study, it was still lower than that observed in controls (35.9+/-4.0 vs 52.9+/-2.2 mumol/min kg FFM). Insulin-induced inhibition of its own secretion was blunted in obese patients (19.9+5.7%, relative to fasting values), and completely reversed to values similar to that of lean ones in the second and third studies (-60.8+/-4.2 and -54.0+/-6.1%, respectively). CONCLUSION: Weight loss in severe obesity improved insulin-induced glucose uptake, and completely normalized the insulin inhibition on its own secretion.
dc.description27
dc.description4
dc.description463
dc.description468
dc.languageen
dc.publisherNature Publishing Group
dc.publisherLondon
dc.publisherInglaterra
dc.relationInternational Journal Of Obesity
dc.relationInt. J. Obes.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectinsulin resistance
dc.subjectinsulin secretion
dc.subjecthyperinsulinemia
dc.subjectC-pepticle
dc.subjectweight loss
dc.subjectbariatric surgery
dc.subjectImpaired Glucose-tolerance
dc.subjectFeedback Inhibition
dc.subjectC-peptide
dc.subjectBeta-cells
dc.subjectHyperinsulinemia
dc.subjectResistance
dc.subjectClearance
dc.subjectReceptor
dc.subjectHumans
dc.subjectPhosphorylation
dc.titleRestored insulin inhibition on insulin secretion in nondiabetic severely obese patients after weight loss induced by bariatric surgery
dc.typeArtículos de revistas


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