IGF-I and INS receptor expression in the salivary glands of diabetic Nod mice submitted to long-term insulin treatment

dc.creatorCaldeira, EJ
dc.creatorCagnon, VHA
dc.date2008
dc.dateJAN
dc.date2014-11-14T17:59:09Z
dc.date2015-11-26T17:16:12Z
dc.date2014-11-14T17:59:09Z
dc.date2015-11-26T17:16:12Z
dc.date.accessioned2018-03-29T00:04:24Z
dc.date.available2018-03-29T00:04:24Z
dc.identifierCell Biology International. Academic Press Ltd Elsevier Science Ltd, v. 32, n. 1, n. 16, n. 21, 2008.
dc.identifier1065-6995
dc.identifierWOS:000260586200003
dc.identifier10.1016/j.cellbi.2007.08.005
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69207
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69207
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69207
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282227
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThis work aimed to characterize the IGF-I and INS receptor expression in the salivary glands of Nod mice, correlating to therapeutic effects of insulin treatment on these receptors. Nod mice were divided into: Groups 1 and 2 (diabetic), Groups 3 and 4 (diabetic with insulin treatment) and Group 5 (non-diabetic). Fragments from the salivary glands were processed for immunohistochemical analysis. The results showed that the prolonged diabetic state led to a steadily increased IGF-I receptor expression. INS receptor expression was gradually decreased. It was concluded that not only was the IGF-I receptor expression affected by the diabetic state but also the INS receptor expression. The period of the diabetic state was directly related to changes in the expression of these receptors. In spite of the insulin treatment having recovered the glycaemic levels, the expression of INS and the IGF-I receptors did not reach the standard level, which certainly hampered glandular function. (C) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
dc.description32
dc.description1
dc.description16
dc.description21
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [03/13377-3]
dc.languageen
dc.publisherAcademic Press Ltd Elsevier Science Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationCell Biology International
dc.relationCell Biol. Int.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectSalivary glands
dc.subjectAutoimmune diabetes
dc.subjectInsulin treatment
dc.subjectIGF-IR
dc.subjectInsulin receptor
dc.subjectGrowth-factor-i
dc.subjectHuman-breast-cancer
dc.subjectBinding-proteins
dc.subjectParotid-gland
dc.subjectMellitus
dc.subjectCells
dc.subjectRats
dc.titleIGF-I and INS receptor expression in the salivary glands of diabetic Nod mice submitted to long-term insulin treatment
dc.typeArtículos de revistas


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