dc.creatorCampos, PRA
dc.creatorDe Oliveira, VM
dc.date2004
dc.dateMAY
dc.date2014-11-14T17:26:19Z
dc.date2015-11-26T17:16:06Z
dc.date2014-11-14T17:26:19Z
dc.date2015-11-26T17:16:06Z
dc.date.accessioned2018-03-29T00:04:18Z
dc.date.available2018-03-29T00:04:18Z
dc.identifierEvolution. Soc Study Evolution, v. 58, n. 5, n. 932, n. 937, 2004.
dc.identifier0014-3820
dc.identifierWOS:000221632700003
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81914
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/81914
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81914
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282204
dc.descriptionWe study the process of fixation of beneficial mutations in an asexual population by means of a theoretical model. Particularly, we wish to investigate how the supply of deleterious and beneficial mutations influences the dynamics of the adaptive process of an evolving population. It is well known that the deleterious mutations drastically affect the fate of beneficial mutations. In addition, an increasing supply of favorable mutations, to compensate the decay of the fitness due to the accumulation of deleterious mutations, produces the clonal interference phenomenon where advantageous mutations in distinct lineages compete to reach fixation. This competition imposes a limit to the speed of adaptation of the population. Intuitively, we would expect that the interplay of the two mechanisms would conspire to ensure fixation of only large-effect beneficial mutations. Our results, however, show that beneficial mutations of small effect have an increased probability of fixation when both beneficial and deleterious mutations rates are increased.
dc.description58
dc.description5
dc.description932
dc.description937
dc.languageen
dc.publisherSoc Study Evolution
dc.publisherLawrence
dc.publisherEUA
dc.relationEvolution
dc.relationEvolution
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectadaptation
dc.subjectadaptive evolution
dc.subjectbeneficial mutations
dc.subjectclonal interference
dc.subjectfixation
dc.subjectBeneficial Mutations
dc.subjectAsexual Populations
dc.subjectRna Viruses
dc.subjectAdaptation
dc.subjectEvolution
dc.subjectAlleles
dc.subjectSelection
dc.subjectFixation
dc.subjectLinkage
dc.subjectNumber
dc.titleMutational effects on the clonal interference phenomenon
dc.typeArtículos de revistas


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