Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity

dc.creatorda Silva, AA
dc.creatorAlbuquerque, S
dc.creatorSilva, MLAE
dc.creatorEberlin, MN
dc.creatorTomazela, DM
dc.creatorBastos, JK
dc.date2004
dc.dateJAN
dc.date2014-11-20T06:03:57Z
dc.date2015-11-26T17:15:50Z
dc.date2014-11-20T06:03:57Z
dc.date2015-11-26T17:15:50Z
dc.date.accessioned2018-03-29T00:04:03Z
dc.date.available2018-03-29T00:04:03Z
dc.identifierJournal Of Natural Products. Amer Chemical Soc, v. 67, n. 1, n. 42, n. 45, 2004.
dc.identifier0163-3864
dc.identifierWOS:000188364400009
dc.identifier10.1021/np0302697
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78632
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/78632
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78632
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282143
dc.descriptionThe phytochemical investigation of the crude ethanol extract of the leaves of Nectandra megapotamica afforded three new (2d, 3b, and 3c) and eight known (1a-d, 2a-c, and 3a) tetrahydrofuran lignans. Regarding the in vitro trypanocidal activity, the lignan-rich fraction, at a concentration of 2.0 mg/mL, was 100% active. Compound 1a was the most active, showing an IC50 value of 2.2 muM and lysis of 94% of the parasites at 32 muM. Compounds 1b, 1d, 2a, 2c, and 3a displayed moderate activity, while compound 1c was inactive.
dc.description67
dc.description1
dc.description42
dc.description45
dc.languageen
dc.publisherAmer Chemical Soc
dc.publisherWashington
dc.publisherEUA
dc.relationJournal Of Natural Products
dc.relationJ. Nat. Prod.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectMyristica-dactyloides
dc.subjectVirola-surinamensis
dc.subjectTrypanosoma-cruzi
dc.subjectConstituents
dc.subjectLauraceae
dc.subjectPlants
dc.titleTetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity
dc.typeArtículos de revistas


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