Myelopoietic response in mice exposed to acute cold/restraint stress: Modulation by Chlorella vulgaris prophylactic treatment

dc.creatorQueiroz, JD
dc.creatorMalacrida, SA
dc.creatorJusto, GZ
dc.creatorQueiroz, MLS
dc.date2004
dc.date2014-11-14T16:44:50Z
dc.date2015-11-26T17:15:42Z
dc.date2014-11-14T16:44:50Z
dc.date2015-11-26T17:15:42Z
dc.date.accessioned2018-03-29T00:03:56Z
dc.date.available2018-03-29T00:03:56Z
dc.identifierImmunopharmacology And Immunotoxicology. Informa Healthcare, v. 26, n. 3, n. 455, n. 467, 2004.
dc.identifier0892-3973
dc.identifier1532-2513
dc.identifierWOS:000224278100012
dc.identifier10.1081/IPH-200026914
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81933
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/81933
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81933
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282110
dc.descriptionIn this study, hematopoietic cells from mice pretreated with CVE and exposed to acute cold/restraint stress were stimulated in the presence of growth factors to form colonies, thus providing accurate information about the modulation of the green algae of the stress-induced changes in the hematopoietic response. Our results demonstrated that exposure to acute stress affected hematopoiesis. Mice exposed for a 2.5-hour time period of cold and restraint presented diminished clonal capacity for CFU-GM content per femur, which was decreased by as much as 50% compared with that in control mice, in spite of the significant increase in serum colony-stimulating activity (CSA). Treatment with 50 mg/kg CVE for 5 days, previously to the stress regimen, attenuates the effects of the stress, since comparable levels of myeloid progenitors were found in the bone marrow of both CVE/stress and control mice. Moreover, the sera from stressed mice pretreated with CVE further increased the CFU-GM formation. On the contrary, the spleen seemed to be less sensitive to acute stress in our experimental conditions. These findings are in line with our previous reports showing that the stress-induced reduction in bone marrow CFU-GM of rats exposed to electric shocks is mediated by activation of the HPA axis and by secretion of opioid agonists.([14,15]) No changes were observed in bone marrow, spleen and thymus total cell counts, and in relative organ weights. However, a 50% reduction in the body weight loss produced by the stress was observed in mice given the extract.
dc.description26
dc.description3
dc.description455
dc.description467
dc.languageen
dc.publisherInforma Healthcare
dc.publisherLondon
dc.publisherInglaterra
dc.relationImmunopharmacology And Immunotoxicology
dc.relationImmunopharmacol. Immunotoxicol.
dc.rightsfechado
dc.rightshttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.sourceWeb of Science
dc.subjectmyelopoiesis
dc.subjectChlorella vulgaris
dc.subjectacute cold/restraint stress
dc.subjectCFU-GM (colony-forming unit-granulocyte-macrophage)
dc.subjectHot-water Extract
dc.subjectEscherichia-coli Infection
dc.subjectUnicellular Green-algae
dc.subjectListeria-monocytogenes
dc.subjectImmobilization Stress
dc.subjectHematopoietic System
dc.subjectImmune Interactions
dc.subjectHost-defense
dc.subjectResistance
dc.subjectRats
dc.titleMyelopoietic response in mice exposed to acute cold/restraint stress: Modulation by Chlorella vulgaris prophylactic treatment
dc.typeArtículos de revistas


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