Lack of lymph node reaction to subcutaneously injected silicone gel: Histological and computer aided morphometric study in rats

dc.creatorTiziani, V
dc.creatorCintra, ML
dc.creatordoAmaral, CMR
dc.creatorSabbatini, RME
dc.creatorLima, RPR
dc.date1995
dc.dateDEC
dc.date2014-07-30T14:36:03Z
dc.date2015-11-26T17:15:33Z
dc.date2014-07-30T14:36:03Z
dc.date2015-11-26T17:15:33Z
dc.date.accessioned2018-03-29T00:03:47Z
dc.date.available2018-03-29T00:03:47Z
dc.identifierScandinavian Journal Of Plastic And Reconstructive Surgery And Hand Surgery. Scandinavian University Press, v. 29, n. 4, n. 303, n. 311, 1995.
dc.identifier0284-4311
dc.identifierWOS:A1995TL39100004
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61068
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61068
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282073
dc.descriptionThe gel of silicone implants may bleed through the elastomeric envelope or may come into contact with the body because of rupture of the implant. We have studied the effects of free silicone gel injected into the subcutaneous space in rats and analysed the morphological features of the axillary and inguinal lymph nodes. Ninety six Wistar rats had 3 cm(3) of silicone gel injected into their subcutaneous space and 96 Wistar rats (the control group) had distilled water injected into their subcutaneous space. The animals were killed on days 1, 3, 7, 9, 15, 30, 60, 90, 12O, 180, 270, and 365 after the injection. There was no detectable silicone and no damage to the lymph nodes on routine histopathological analysis. Small amounts of silicone that could migrate to lymph nodes could result in hyperplasia. To evaluate this possibility, a morphometric study based on a computer aided system compared the area of lymph node sections between treated and control animals, and showed no difference between treated and control groups. If silicone did migrate, it did not provoke morphological signs or hyperplasia in the lymph nodes.
dc.description29
dc.description4
dc.description303
dc.description311
dc.languageen
dc.publisherScandinavian University Press
dc.publisherOslo
dc.publisherNoruega
dc.relationScandinavian Journal Of Plastic And Reconstructive Surgery And Hand Surgery
dc.relationScand. J. Plast. Reconstr. Surg. Hand Surg.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectsilicone gel
dc.subjectlymphadenopathy
dc.subjectcomputer aided morphometry
dc.subjectsilicone reactions
dc.subjectsilicone migration
dc.subjectexperimental research
dc.subjecthistopathological analysis
dc.subjectConcomitant Malignant-lymphoma
dc.subjectFinger Joint Prostheses
dc.subjectBreast Implants
dc.subjectLymphadenopathy
dc.titleLack of lymph node reaction to subcutaneously injected silicone gel: Histological and computer aided morphometric study in rats
dc.typeArtículos de revistas


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