Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: role of oxygen free radicals generation

dc.creatorVillegas, I
dc.creatorMartin, AR
dc.creatorToma, W
dc.creatorde la Lastra, CA
dc.date2004
dc.date47058
dc.date2014-11-14T12:35:09Z
dc.date2015-11-26T17:15:02Z
dc.date2014-11-14T12:35:09Z
dc.date2015-11-26T17:15:02Z
dc.date.accessioned2018-03-29T00:03:16Z
dc.date.available2018-03-29T00:03:16Z
dc.identifierEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 505, n. 41699, n. 195, n. 203, 2004.
dc.identifier0014-2999
dc.identifierWOS:000225419000023
dc.identifier10.1016/j.ejphar.2004.10.020
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75761
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/75761
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75761
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281944
dc.descriptionPeroxisome pro liferator-activated receptor gamma (PPAR-gamma) is a nuclear hormone receptor super family that has recently been implicated in atherosclerosis, inflammation, cancer, infertility, and demyelination. Oxidative stress, neutrophil infiltration, proinflammatory cytokines, and the exhibition of luminal acid play a role in the pathogenesis of gastric injury induced by ischemia-reperfusion. Rosiglitazone, a specific PPAR-gamma ligand, has been shown to have anti inflammatory activity, but its effects on experimental ischemia-reperfusion gastric injury remain unknown. We have investigated the effects of the rosiglitazone on gastric injury caused by ischemia following reperfusion in rats. Tumour necrosis factor-alpha (TNF-alpha) levels and changes in enzymatic activities of myeloperoxidase, as a marker of neutrophils infiltration, xanthine oxidase, superoxide dismutase, and glutathione peroxidase, were determined. Histological analysis of the lesions was also carried out. Pretreatment with 1 or 4 mg/kg of rosiglitazone ameliorated the gastric damage induced by clamping the celiac artery for 30 min followed by 60 min of reperfusion. It significantly (P < 0.05) reduced the index of neutrophil infiltration and the levels of the cytokine. Rosiglitazone did not revert the reduced glutathione peroxidase activity but enhanced significantly (P < 0.01) the decreased xanthine oxidase and superoxide dismutase activities in gastric mucosa of ischemic rats. In conclusion, rosiglitazone reduces the damage in ischemia-reperfusion gastric injury and alleviates the inflammatory response and the oxidative events. (C) 2004 Elsevier B.V. All rights reserved.
dc.description505
dc.description41699
dc.description195
dc.description203
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectPPAR-gamma
dc.subjectrosiglitazone
dc.subjectischemia-reperfusion
dc.subjectreactive oxygen specie
dc.subjectneutrophil
dc.subjectcyclooxygenase
dc.subjectPpar-gamma
dc.subjectMucosal Injury
dc.subjectIschemia/reperfusion Injury
dc.subjectNitric-oxide
dc.subjectLigand
dc.subjectPioglitazone
dc.subjectMelatonin
dc.subjectStress
dc.subjectIschaemia/reperfusion
dc.subjectCyclooxygenase
dc.titleRosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: role of oxygen free radicals generation
dc.typeArtículos de revistas


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