The influence of type I diabetes mellitus in periodontal disease induced changes of the gingival epithelium and connective tissue

dc.creatorSilva, JAF
dc.creatorLorencini, M
dc.creatorReis, JRR
dc.creatorCarvalho, HF
dc.creatorCagnon, VHA
dc.creatorStach-Machado, DR
dc.date2008
dc.dateAUG
dc.date2014-11-14T13:08:09Z
dc.date2015-11-26T17:15:00Z
dc.date2014-11-14T13:08:09Z
dc.date2015-11-26T17:15:00Z
dc.date.accessioned2018-03-29T00:03:15Z
dc.date.available2018-03-29T00:03:15Z
dc.identifierTissue & Cell. Churchill Livingstone, v. 40, n. 4, n. 283, n. 292, 2008.
dc.identifier0040-8166
dc.identifierWOS:000258044800006
dc.identifier10.1016/j.tice.2008.02.002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73524
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/73524
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73524
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281937
dc.descriptionPeriodontal disease constitutes the most frequent chronic diseases in human dentition. Bacterial plaque is the main etiologic agent, although it is the host immune response that causes periodontal tissue destruction. Diabetes is considered an important risk factor, not only for the onset but also for progression of the disease. The aim of this study was to analyze structural changes in the rat gingival epithelium and connective tissue in response to the experimental periodontal disease induced by the ligature technique, under the influence of diabetes. The results showed that experimental periodontal disease is characterized by marked inflammation, affecting both the epithelial and connective tissues, causing degeneration of the dermal papilla, increase in the number of inflammatory cells, destruction of reticulin fibers, and accumulation of dense collagen fibers (fibrosis). These changes were worsened by diabetes, apparently by hampering the inflammatory response and affecting tissue repair of the affected tissues. (c) 2008 Elsevier Ltd. All rights reserved.
dc.description40
dc.description4
dc.description283
dc.description292
dc.languageen
dc.publisherChurchill Livingstone
dc.publisherEdinburgh
dc.publisherEscócia
dc.relationTissue & Cell
dc.relationTissue Cell
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectdiabetes mellitus
dc.subjectexperimental periodontal disease
dc.subjectstreptozotocin
dc.subjectinflammation
dc.subjectfibrosis
dc.subjectCytokine Profile
dc.subjectCell Biology
dc.subjectPathogenesis
dc.subjectRat
dc.subjectInflammation
dc.titleThe influence of type I diabetes mellitus in periodontal disease induced changes of the gingival epithelium and connective tissue
dc.typeArtículos de revistas


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