Adverse effect of the anabolic-androgenic steroid mesterolone on cardiac remodelling and lipoprotein profile is attenuated by aerobicz exercise training

dc.creatorFontana, K
dc.creatorOliveira, HCF
dc.creatorLeonardo, MB
dc.creatorMandarim-de-Lacerda, CA
dc.creatorda Cruz-Hofling, MA
dc.date2008
dc.dateOCT
dc.date2014-11-14T12:24:51Z
dc.date2015-11-26T17:14:52Z
dc.date2014-11-14T12:24:51Z
dc.date2015-11-26T17:14:52Z
dc.date.accessioned2018-03-29T00:03:08Z
dc.date.available2018-03-29T00:03:08Z
dc.identifierInternational Journal Of Experimental Pathology. Wiley-blackwell, v. 89, n. 5, n. 358, n. 366, 2008.
dc.identifier0959-9673
dc.identifierWOS:000259149600007
dc.identifier10.1111/j.1365-2613.2008.00601.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/76940
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/76940
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/76940
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281905
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAbuse of anabolic-androgenic steroids (AAS) for improving physical performance is associated with serious, sometimes fatal, adverse effects. The aim of the present work was to investigate the effects of AAS on the cardiac structure and the plasma lipoprotein profile isolated and in combination with exercise. Transgenic mice with a human lipaemic phenotype (expressing cholesteryl ester transfer protein on the LDL receptor knockout background) were used in this study. Sedentary and exercised mice (treadmill running, five times per week for 6 weeks) were treated with mesterolone (2 mu g/g body weight) or vehicle (control-C) in the last 3 weeks. Four groups were compared: (i) exercise + mesterolone (Ex-M), (ii) exercise + vehicle (Ex-C), (iii) sedentary + mesterolone (Sed-M) and (iv) sedentary + vehicle (Sed-C). Arterial blood pressure and body mass increased in all groups along time, but Sed-M reached the highest values and Ex-C the lowest. Treatment with mesterolone increased total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-c) and very LDL-c (VLDL-c) plasma levels. However, exercise blunted some of these deleterious effects by increasing high-density lipoprotein cholesterol and decreasing LDL-c, VLDL-c and triglycerides. Exercise training induced beneficial effects, such as physiological cardiomyocyte hypertrophy, increase in myocardial circulation and decrease in cardiac interstitium. However, mesterolone impaired such physiological gains and in addition increased troponin T plasma levels both in sedentary and exercised mice. Thus, while mesterolone induced pro-atherogenic lipoprotein profile and pathogenic cardiac hypertrophy, exercise counteracted these effects and modified favourably both the lipoprotein profile and the cardiac remodelling induced by mesterolone.
dc.description89
dc.description5
dc.description358
dc.description366
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [Proc. 04/13767-9, Proc. 04/13768-5]
dc.descriptionCNPq [Proc. 522131/95-6]
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationInternational Journal Of Experimental Pathology
dc.relationInt. J. Exp. Pathol.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectcardiac interstitium
dc.subjectcardiomyocytes
dc.subjectlipid profile
dc.subjectmesterolone
dc.subjecttransgenic murine model
dc.subjectventricular hypertrophy
dc.subjectSpontaneously Hypertensive-rats
dc.subjectLow-density-lipoprotein
dc.subjectCapillary Bed
dc.subjectLipid Levels
dc.subjectOlder Men
dc.subjectCholesterol
dc.subjectTestosterone
dc.subjectPlasma
dc.subjectAtherosclerosis
dc.subjectExpression
dc.titleAdverse effect of the anabolic-androgenic steroid mesterolone on cardiac remodelling and lipoprotein profile is attenuated by aerobicz exercise training
dc.typeArtículos de revistas


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