Quality of life and adverse events after radiotherapy in gynecologic cancer survivors: a cohort study

dc.creatorVaz, AF
dc.creatorConde, DM
dc.creatorCosta-Paiva, L
dc.creatorMorais, SS
dc.creatorEsteves, SB
dc.creatorPinto-Neto, AM
dc.date2011
dc.dateDEC
dc.date2014-07-30T14:18:51Z
dc.date2015-11-26T17:14:28Z
dc.date2014-07-30T14:18:51Z
dc.date2015-11-26T17:14:28Z
dc.date.accessioned2018-03-29T00:02:46Z
dc.date.available2018-03-29T00:02:46Z
dc.identifierArchives Of Gynecology And Obstetrics. Springer Heidelberg, v. 284, n. 6, n. 1523, n. 1531, 2011.
dc.identifier0932-0067
dc.identifierWOS:000296632500029
dc.identifier10.1007/s00404-011-1886-x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58551
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58551
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281817
dc.descriptionPurpose To evaluate quality of life (QOL) in gynecologic cancer survivors after radiotherapy (RT), investigate the frequency of adverse events and demonstrate an association between these symptoms and QOL. Methods A prospective cohort study of 95 women aged 21-75 years undergoing RT for gynecologic cancer was carried out. QOL was assessed by the WHOQOL-BREF before, at 4 months, 1 year and 3 years after RT and adverse events were evaluated following RT by the (CTCAE) v 3.0 scale. QOL scores were assessed by the Wilcoxon signed rank test over time. Multiple linear regression analysis was used to identify predictors of QOL. Results The most frequent adverse events were pain (64.2%) and dyspareunia (45.9%). A significant increase in QOL scores was observed in the psychological domain, general health and overall QOL. Pain was negatively associated with the physical, psychological and social relationship domains (p < 0.01); dyspareunia with the physical and social relationship (p < 0.01); decreased sexual interest with the psychological (p < 0.01). Higher family income was positively associated with the psychological domain and general health (p < 0.01). Conclusions Results suggested that QOL improved after RT in women with gynecologic cancer. Adverse events, such as pain, dyspareunia and decreased sexual interest had a negative impact on QOL.
dc.description284
dc.description6
dc.description1523
dc.description1531
dc.languageen
dc.publisherSpringer Heidelberg
dc.publisherHeidelberg
dc.publisherAlemanha
dc.relationArchives Of Gynecology And Obstetrics
dc.relationArch. Gynecol. Obstet.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectGynecologic cancer
dc.subjectQuality of life
dc.subjectAdverse events
dc.subjectRadiotherapy
dc.subjectCervical-cancer
dc.subjectPelvic Radiotherapy
dc.subjectSexual Function
dc.subjectVaginal Changes
dc.subjectWhoqol-bref
dc.subjectFollow-up
dc.subjectHealth
dc.subjectWomen
dc.subjectToxicity
dc.subjectMorbidity
dc.titleQuality of life and adverse events after radiotherapy in gynecologic cancer survivors: a cohort study
dc.typeArtículos de revistas


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