Human papillomavirus (HPV) infections as risk factors for cytological and histological abnormalities in baseline PAP smear-negative women followed-up for 2 years in the LAMS study

dc.creatorGontijo, RC
dc.creatorDerchain, SFM
dc.creatorRoteli-Martins, C
dc.creatorBraganqa, JF
dc.creatorSarian, LO
dc.creatorMorais, SS
dc.creatorMaeda, MYS
dc.creatorLongatto-Filho, A
dc.creatorSyrjadnen, KJ
dc.date2007
dc.dateAUG
dc.date2014-11-14T10:05:08Z
dc.date2015-11-26T17:14:26Z
dc.date2014-11-14T10:05:08Z
dc.date2015-11-26T17:14:26Z
dc.date.accessioned2018-03-29T00:02:45Z
dc.date.available2018-03-29T00:02:45Z
dc.identifierEuropean Journal Of Obstetrics Gynecology And Reproductive Biology. Elsevier Ireland Ltd, v. 133, n. 2, n. 239, n. 246, 2007.
dc.identifier0301-2115
dc.identifierWOS:000248981300020
dc.identifier10.1016/j.ejogrb.2006.05.012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68916
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/68916
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68916
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281811
dc.descriptionObjective: To assess the role of HPV as determinant of the incident cytological abnormalities (SIL) and cervical lesions (CIN) during a 24-month follow-up of baseline PAP smear-negative subgroup of women included in the Latin American Screening study (LAMS). Study design: A group of 365 women with normal Pap smear and negative or positive high-risk Hybrid Capture 11 test were prospectively followed-up for 24 months at Campinas and Sao Paulo (Brazil). The incidence rate (IR) and risk ratio (RR and 95% Cl) of developing cytological or histological abnormality during the follow-up was calculated for HPV-negative and HPV-positive women. Results: During, the 12-month follow-up, women HPV-positive at baseline had developed a significantly higher rate of incident LSIL (IR = 3.5%. RR = 1.4 - 95% Cl 1.1-1.7) and HSIL (IR = 0.7%, RR = 1.5; 95% Cl 1.4-1.7) abnormality. For HSIL, the IR increased to 2. 1 % and the RR increased to 1.7 (95% CI 1.5-1.9) among those followed for 24 months. Similarly, women with positive HPV tests were at a higher risk of developing CIN 2-3 (IR = 2.6%, RR = 1.5; 95% Cl 1.4-1.6) during the first 12 months of follow-up, and for those followed for 24 months, this RR increased further to 1.7 (95% CI 1.5-1.9) although the IR was 0.7%. Conclusions: Oncouenic HPV infections comprise a significant risk factor for incident cervical abnormalities, and HPV test is a useful adjunct to cytology in detecting the high-risk patients among baseline PAP smear-negative women. (c) 2006 Published by Elsevier Ireland Ltd.
dc.description133
dc.description2
dc.description239
dc.description246
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology
dc.relationEur. J. Obstet. Gynecol. Reprod. Biol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectnegative cytology
dc.subjectHPV
dc.subjecthybrid capture II
dc.subjectfollow-up
dc.subjectCIN
dc.subjectincident abnormalities
dc.subjectGrade Cervical Lesions
dc.subjectScreening Tools
dc.subjectSexual-behavior
dc.subjectLatin-america
dc.subjectCancer
dc.subjectNeoplasia
dc.subjectPopulation
dc.subjectBenefits
dc.subjectSmoking
dc.subjectSelects
dc.titleHuman papillomavirus (HPV) infections as risk factors for cytological and histological abnormalities in baseline PAP smear-negative women followed-up for 2 years in the LAMS study
dc.typeArtículos de revistas


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