Hyaluronan in vaginal secretions: association with recurrent vulvovaginal candidiasis

dc.creatorLev-Sagie, A
dc.creatorNyirjesy, P
dc.creatorTarangelo, N
dc.creatorBongiovanni, AM
dc.creatorBayer, C
dc.creatorLinhares, IM
dc.creatorGiraldo, PC
dc.creatorLedger, WJ
dc.creatorWitkin, SS
dc.date2009
dc.dateAUG
dc.date2014-11-14T10:23:16Z
dc.date2015-11-26T17:14:22Z
dc.date2014-11-14T10:23:16Z
dc.date2015-11-26T17:14:22Z
dc.date.accessioned2018-03-29T00:02:42Z
dc.date.available2018-03-29T00:02:42Z
dc.identifierAmerican Journal Of Obstetrics And Gynecology. Mosby-elsevier, v. 201, n. 2, 2009.
dc.identifier0002-9378
dc.identifierWOS:000268460900028
dc.identifier10.1016/j.ajog.2009.05.010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68945
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/68945
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68945
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281798
dc.descriptionOBJECTIVE: We evaluated whether vaginal concentrations of hyaluronan were altered in women with recurrent vulvovaginal candidiasis (RVVC). STUDY DESIGN: Lavage samples from 17 women with acute RVVC, 27 women who were receiving a maintenance antifungal regimen, and 24 control women were tested for hyaluronan and interleukin (IL)-6, IL-12, and IL-23 by enzyme-linked immunosorbent assay. RESULTS: Median vaginal hyaluronan concentrations were 33.8 ng/mL (range, 21.6-66.3 ng/mL) in women with acute RVVC, 15.0 ng/mL (range, 11.2-50.6 ng/mL) in women who were receiving maintenance therapy, and 4.2 ng/mL (range, 3.6-12.0 ng/mL) in control subjects (P <= .02). The vaginal hyaluronan concentration was 27.4 ng/mL (range, 15.4-37.7 ng/mL) when Candida was detected by microscopy and 9.5 ng/mL (range, 7.7-14.6 ng/mL) in microscopy-negative cases (P = .0354). Elevated hyaluronan levels were associated with itching plus burning (40.7 ng/mL) or itching plus discharge (42.1 ng/mL), as opposed to itching only (6.2 ng/mL; P = .0152). Hyaluronan and IL-6 levels were correlated (P = .0009). CONCLUSION: Hyaluronan release is a component of the host response to a candidal infection and may contribute to symptoms.
dc.description201
dc.description2
dc.languageen
dc.publisherMosby-elsevier
dc.publisherNew York
dc.publisherEUA
dc.relationAmerican Journal Of Obstetrics And Gynecology
dc.relationAm. J. Obstet. Gynecol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectanti-Candida maintenance therapy
dc.subjecthyaluronan
dc.subjectrecurrent vulvovaginal candidiasis
dc.subjectvaginal lavage
dc.subjectMannose-binding Lectin
dc.subjectMolecular-weight Hyaluronan
dc.subjectOral Epithelial-cells
dc.subjectAnticandida Activity
dc.subjectGene Polymorphism
dc.subjectPotential Role
dc.subjectWomen
dc.subjectVaginitis
dc.subjectTherapy
dc.subjectAcid
dc.titleHyaluronan in vaginal secretions: association with recurrent vulvovaginal candidiasis
dc.typeArtículos de revistas


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