Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters

dc.creatorAmaral, ME
dc.creatorBarbuio, R
dc.creatorMilanski, M
dc.creatorRomanatto, T
dc.creatorBarbosa, HC
dc.creatorNadruz, W
dc.creatorBertolo, MB
dc.creatorBoschero, AC
dc.creatorSaad, MJA
dc.creatorFranchini, KG
dc.creatorVelloso, LA
dc.date2006
dc.dateJUL
dc.date2014-11-14T06:46:55Z
dc.date2015-11-26T17:13:44Z
dc.date2014-11-14T06:46:55Z
dc.date2015-11-26T17:13:44Z
dc.date.accessioned2018-03-29T00:02:05Z
dc.date.available2018-03-29T00:02:05Z
dc.identifierJournal Of Neurochemistry. Blackwell Publishing, v. 98, n. 1, n. 203, n. 212, 2006.
dc.identifier0022-3042
dc.identifierWOS:000238255900019
dc.identifier10.1111/j.1471-4159.2006.03857.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77062
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77062
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77062
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281642
dc.descriptionTumor necrosis factor-alpha (TNF-alpha) is known to participate in the wastage syndrome that accompanies cancer and severe infectious diseases. More recently, a role for TNF-alpha in the pathogenesis of type 2 diabetes mellitus and obesity has been shown. Much of the regulatory action exerted by TNF-alpha upon the control of energy stores depends on its action on the hypothalamus. In this study, we show that TNF-alpha activates canonical pro-inflammatory signal transduction pathways in the hypothalamus of rats. These signaling events lead to the transcriptional activation of an early responsive gene and to the induction of expression of cytokines and a cytokine responsive protein such as interleukin-1 beta, interleukin-6, interleukin-10 and suppressor of cytokine signalling-3, respectively. In addition, TNF-alpha induces the expression of neurotransmitters involved in the control of feeding and thermogenesis. Thus, TNF-alpha may act directly in the hypothalamus inducing a pro-inflammatory response and the modulation of expression of neurotransmitters involved in energy homeostasis.
dc.description98
dc.description1
dc.description203
dc.description212
dc.languageen
dc.publisherBlackwell Publishing
dc.publisherOxford
dc.publisherInglaterra
dc.relationJournal Of Neurochemistry
dc.relationJ. Neurochem.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectactivator protein-1
dc.subjectcachexia
dc.subjectc-Jun kinase
dc.subjectinflammation
dc.subjectobesity
dc.subjecttumor necrosis factor
dc.subjectCentral-nervous-system
dc.subjectCorticotropin-releasing Hormone
dc.subjectTnf-alpha
dc.subjectInsulin-resistance
dc.subjectCytokine Signaling-3
dc.subjectDiabetes-mellitus
dc.subjectRat Hypothalamus
dc.subjectAngiotensin-ii
dc.subjectMessenger-rna
dc.subjectIn-vitro
dc.titleTumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic/anorexigenic neurotransmitters
dc.typeArtículos de revistas


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