Endothelial nitric oxide synthase haplotypes affect the susceptibility to hypertension in patients with type 2 diabetes mellitus

dc.creatorSandrim, VC
dc.creatorde Syllos, RWC
dc.creatorLisboa, HRK
dc.creatorTres, GS
dc.creatorTanus-Santos, JE
dc.date2006
dc.dateNOV
dc.date2014-11-20T03:58:01Z
dc.date2015-11-26T17:13:43Z
dc.date2014-11-20T03:58:01Z
dc.date2015-11-26T17:13:43Z
dc.date.accessioned2018-03-29T00:02:04Z
dc.date.available2018-03-29T00:02:04Z
dc.identifierAtherosclerosis. Elsevier Ireland Ltd, v. 189, n. 1, n. 241, n. 246, 2006.
dc.identifier0021-9150
dc.identifierWOS:000241467900031
dc.identifier10.1016/j.atherosclerosis.2005.12.011
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64772
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/64772
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64772
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281638
dc.descriptionType 2 diabetes mellitus (T2DM) and hypertension (HT) commonly coexist. While endothelial nitric oxide synthase (eNOS) haplotypes have been associated with HT, it is unknown whether eNOS genotypes/haplotypes are associated with altered susceptibility to HT in patients with T2DM. We studied the distribution of three eNOS genetic polymorphisms: a single nucleotide polymorphism in the promoter region (T(-786)C), in exon 7 (Glu298Asp), and a variable number of tandem repeats in intron 4 (b/a). Genotypes were determined for 102 healthy controls, 119 patients with HT, 66 patients with T2DM, and 113 patients with T2DM + HT. In addition, we also compared the distribution of eNOS haplotypes in the four groups of subjects. No differences were found in genotype and allele distribution among the four groups. Conversely, the haplotypes "C Glu b" and "C Asp V were, respectively, more and less common in healthy controls than in HT or in T2DM + HT groups (24% versus 6% and 5%, respectively; both P < 0.00625; and 8% versus 18% and 18%, respectively; both P < 0.00625). Moreover, DM patients presented an overall distribution of eNOS haplotypes that was not different from healthy controls (P > 0.05). Additionally, the haplotypes "C Glu V and "C Asp V were, respectively, more and less common in T2DM group than in T2DM+HT group (19% versus 5%; and 7% versus 18%, respectively; both P < 0.00625). Our findings suggest a protective effect for eNOS haplotype "C Glu b" against the development of hypertension, and that haplotype "C Asp V increases the susceptibility to hypertension in patients without or with T2DM. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
dc.description189
dc.description1
dc.description241
dc.description246
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationAtherosclerosis
dc.relationAtherosclerosis
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectdiabetes mellitus
dc.subjecthypertension
dc.subjectendothelial nitric oxide synthase
dc.subjecthaplotypes
dc.subjectpolymorphisms
dc.subjectLeft-ventricular Mass
dc.subjectBlood-pressure
dc.subjectGlu298asp Polymorphism
dc.subjectGene Polymorphisms
dc.subjectAssociation Analyses
dc.subjectVascular-disease
dc.subjectRisk-factors
dc.subjectNephropathy
dc.subjectMutation
dc.subjectTherapy
dc.titleEndothelial nitric oxide synthase haplotypes affect the susceptibility to hypertension in patients with type 2 diabetes mellitus
dc.typeArtículos de revistas


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