Liposomal encapsulation improves the duration of soft tissue anesthesia but does not induce pulpal anesthesia

dc.creatorFranz-Montan, M
dc.creatorSilva, ALR
dc.creatorFraceto, LF
dc.creatorVolpato, MC
dc.creatorde Paula, E
dc.creatorRanali, J
dc.creatorGroppo, FC
dc.date2010
dc.dateAUG
dc.date2014-11-14T05:13:30Z
dc.date2015-11-26T17:13:29Z
dc.date2014-11-14T05:13:30Z
dc.date2015-11-26T17:13:29Z
dc.date.accessioned2018-03-29T00:01:51Z
dc.date.available2018-03-29T00:01:51Z
dc.identifierJournal Of Clinical Anesthesia. Elsevier Science Inc, v. 22, n. 5, n. 313, n. 317, 2010.
dc.identifier0952-8180
dc.identifierWOS:000280532800002
dc.identifier10.1016/j.jclinane.2010.03.001
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81219
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/81219
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81219
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281582
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionStudy Objective: To compare the topical and the pulpal anesthesia efficacy of liposomal and plain benzocaine formulations Design: Double-blinded, randomized crossover study. Setting: University ambulatory dental center Patients: 30 ASA physical status 1 volunteers Interventions: Volunteers received, in three different sessions, topical application of liposome-encapsulated 10% benzocaine (LB10), 10% benzocaine gel (B10), and 20% benzocaine gel (B20) in the right maxillary canine mucobuccal fold Measurements: Pain associated with the needle insertion was rated by visual analog scale (VAS) and the duration of topical anesthesia was recorded Pulpal anesthesia was evaluated using an electric pulp tester Main Results: VAS values (median. 1st - 3rd quartiles) were 17 cm (11 - 25), 14 cm (3 - 22), and 21 cm (9 21) for B10, LB10, and 1320, respectively No differences were noted among the groups (Friedman test, P = 0 58) Soft tissue anesthesia was also not different The LB10 [10 (8 - 12) min] showed longer soft tissue anesthesia (Friedman test, P < 0 01) than the other agents [1310 = 8 (5 - 10) min, and B20 = 7 (6 - 9) min] None of the topical benzocaine formulations tested induced pulpal anesthesia Conclusions: The encapsulation of benzocaine into liposome increased the duration of soft tissue anesthesia However, it did not induce pulpal anesthesia (C) 2010 Elsevier Inc All rights reserved
dc.description22
dc.description5
dc.description313
dc.description317
dc.descriptionDFL Ind Corn Ltda, Rio de Janeiro, Brazil
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.publisherEUA
dc.relationJournal Of Clinical Anesthesia
dc.relationJ. Clin. Anesth.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectBenzocaine
dc.subjectDentistry
dc.subjectDrug encapsulation
dc.subjectInjection pain
dc.subjectLiposome
dc.subjectLocal anesthetic
dc.subjectTopical anesthesia
dc.subjectIn-vivo Evaluation
dc.subjectTopical Anesthesia
dc.subjectLidocaine
dc.subjectMethemoglobinemia
dc.subjectBenzocaine
dc.subjectBupivacaine
dc.subjectPrilocaine
dc.subjectChildren
dc.subjectEmla
dc.subjectPain
dc.titleLiposomal encapsulation improves the duration of soft tissue anesthesia but does not induce pulpal anesthesia
dc.typeArtículos de revistas


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