Hypotensive properties and acute toxicity of trans-[Ru(NH3)(4)P(OEt)(3)(NO)](PF6)(3), a new nitric oxide donor

dc.creatorTorsoni, AS
dc.creatorde Barros, BF
dc.creatorToledo, JC
dc.creatorHaun, M
dc.creatorKrieger, MH
dc.creatorTfouni, E
dc.creatorFranco, DW
dc.date2002
dc.dateMAY
dc.date2014-11-14T05:29:03Z
dc.date2015-11-26T17:13:28Z
dc.date2014-11-14T05:29:03Z
dc.date2015-11-26T17:13:28Z
dc.date.accessioned2018-03-29T00:01:50Z
dc.date.available2018-03-29T00:01:50Z
dc.identifierNitric Oxide-biology And Chemistry. Academic Press Inc Elsevier Science, v. 6, n. 3, n. 247, n. 254, 2002.
dc.identifier1089-8603
dc.identifierWOS:000175734100001
dc.identifier10.1006/niox.2001.0409
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69081
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69081
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69081
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281578
dc.descriptionThe hypotensive effect and the acute toxicity of trans-[Ru(NH3)(4)P(OEt)(3)(NO)](PF6)(3) (RuNO) were investigated in conscious animals. The approximate lethal dose of RuNO is 257.5 mumol/kg in mice i.p. and the IC50 values evaluated for V79 culture cell cytotoxicity were higher than 2.0 mM, suggesting that the ruthenium species are significantly less toxic than Na-2[Fe(CN)(5)(NO)] (SN-P) species. The RuNO hypotensive effect measured through in-bolus intravenous administration in chronically instrumented normotensive and hypotensive adult male Wistar rats is similar to that exhibited by equivalent doses of SNP. The hypotensive effect of the ruthenium complex is fully inhibited by methylene blue and PTIO, suggesting that the RuNO effect is likely to be primarily dependent on the NO-[cGMP] pathway in the smooth muscle cells. (C) 2002 Elsevier Science (USA).
dc.description6
dc.description3
dc.description247
dc.description254
dc.languageen
dc.publisherAcademic Press Inc Elsevier Science
dc.publisherSan Diego
dc.publisherEUA
dc.relationNitric Oxide-biology And Chemistry
dc.relationNitric Oxide-Biol. Chem.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectnitric oxide donor
dc.subjectnitrovasodilator
dc.subjectblood pressure
dc.subjectmetal-nitrosyl complexes
dc.subjectsodium nitroprusside
dc.subjectmethylene blue
dc.subjectcarboxy-PTIO
dc.subjectSoluble Guanylate-cyclase
dc.subjectNo-center-dot
dc.subjectRuthenium Complexes
dc.subjectNitrosyl Complexes
dc.subjectTransgenic Mice
dc.subjectPharmacology
dc.subjectOxygen
dc.subjectLigand
dc.titleHypotensive properties and acute toxicity of trans-[Ru(NH3)(4)P(OEt)(3)(NO)](PF6)(3), a new nitric oxide donor
dc.typeArtículos de revistas


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