Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis

dc.creatorCorvino, CL
dc.creatorMamoni, RL
dc.creatorFagundes, GZZ
dc.creatorBlotta, MHSL
dc.date2007
dc.dateMAR
dc.date2014-11-14T05:05:47Z
dc.date2015-11-26T17:13:27Z
dc.date2014-11-14T05:05:47Z
dc.date2015-11-26T17:13:27Z
dc.date.accessioned2018-03-29T00:01:50Z
dc.date.available2018-03-29T00:01:50Z
dc.identifierClinical And Experimental Immunology. Wiley-blackwell, v. 147, n. 3, n. 483, n. 490, 2007.
dc.identifier0009-9104
dc.identifierWOS:000243928900012
dc.identifier10.1111/j.1365-2249.2006.03308.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75669
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/75669
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75669
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281575
dc.descriptionInterleukin (IL)-18 is a proinflammatory cytokine of the IL-1 superfamily that exhibits broad functional effects in innate and acquired immune responses and which has been found in high levels in several chronic inflammatory and autoimmune diseases. Over-expression of IL-18 may promote early resolution of infection or could promote a detrimental exaggerated immune response. The aim of this study was to determine serum levels of IL-18 and other inflammatory mediators [IL-12, soluble intercellular adhesion molecule 1 (sICAM-1), soluble tumour necrosis factor receptor 1 (TNF-RI), sTNF-RII, CXC chemokine ligand 9 (CXCL9), CXCL10] at baseline and after anti-fungal therapy in serum from patients with juvenile (JF) and adult (AF) forms of paracoccidioidomycosis (PCM), as well as in healthy controls (C), and to assess their possible relationships to the severity of disease. IL-18 and sTNF-RII levels in patients with the JF of PCM were significantly higher than those in the AF and controls. In relation to sICAM-1, no difference was observed between JF and AF patients but both presented higher levels than controls. sTNF-RI levels were higher in patients with PCM than in controls, and significantly higher concentrations were detected in AF patients compared to JF patients. Moreover, IL-12 and chemokines CXCL9 and CXCL10 were also higher in patients than in controls. In JF patients IL-18 levels correlated significantly with sICAM-1 (r = 0.62, P < 0.0001), sTNF-RI (r = 0.63, P < 0.0001), sTNF-RII (r = 0.51, P = 0.02), as well as with clinical severity. The results suggest the value of serum IL-18 and sTNF-Rs levels as a parameter of PCM severity and may support a possible role for them in the pathogenesis of the disease.
dc.description147
dc.description3
dc.description483
dc.description490
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationClinical And Experimental Immunology
dc.relationClin. Exp. Immunol.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectchemokines
dc.subjectIL-18
dc.subjectparacoccidioidomycosis
dc.subjectsICAM-1
dc.subjectsTNF-RII
dc.subjectTumor-necrosis-factor
dc.subjectIfn-gamma Production
dc.subjectInterferon-gamma
dc.subjectT-cells
dc.subjectIn-vitro
dc.subjectBrasiliensis Infection
dc.subjectFactor Receptors
dc.subjectIl-18
dc.subjectExpression
dc.subjectChemokine
dc.titleSerum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución