Hyperhomocysteinaemia-induced cardiovascular changes in rats

dc.creatorResstel, LBM
dc.creatorde Andrade, CR
dc.creatorHaddad, R
dc.creatorEberlin, MN
dc.creatorde Oliveira, AM
dc.creatorCorrea, FMA
dc.date2008
dc.dateAUG
dc.date2014-11-14T05:50:03Z
dc.date2015-11-26T17:13:23Z
dc.date2014-11-14T05:50:03Z
dc.date2015-11-26T17:13:23Z
dc.date.accessioned2018-03-29T00:01:46Z
dc.date.available2018-03-29T00:01:46Z
dc.identifierClinical And Experimental Pharmacology And Physiology. Wiley-blackwell, v. 35, n. 8, n. 949, n. 956, 2008.
dc.identifier0305-1870
dc.identifierWOS:000257476100016
dc.identifier10.1111/j.1440-1681.2008.04940.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69056
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69056
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69056
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281560
dc.description1. Increased plasma homocysteine content and increased blood pressure are independently associated with higher cardiovascular risks. The present study was designed to determine the effects of hyperhomocysteinaemia (HHcys) on the activity of the cardiovascular system in rats. 2. Using male Wistar rats, the effect of moderate HHcys, induced by treating rats with DL-homocysteine thiolactone (DL-HT; 1 g/kg per day) for 15 days, on arterial blood pressure, heart rate, baroreflex and vascular reactivity was determined. 3. Hyperhomocysteinaemia was observed after 15 days of treatment. Baseline arterial blood pressure and heart rate values of HHcys animals were significantly increased after 15 days of treatment. Plasma homocysteine and cardiovascular parameters returned to control values after termination of treatment. Baroreflex gain was significantly enhanced in HHcys rats. The pressor effect of an i.v. infusion of phenylephrine (50 mg/kg per mL) was decreased in HHcys rats and returned to control values after washout of DL-HT. Hypotensive responses to i.v. infusions of sodium nitroprusside (70 mg/kg per mL) or acetylcholine (10 mg/kg per mL) were increased in HHcys animals and returned to control values after washout of DL-HT. The increase in resting arterial blood pressure associated with the moderate HHcys was reversed by treatment with the b(1)-adrenoceptor antagonist atenolol, suggesting that HHcys-related hypertension is related to increase in cardiac sympathetic activity. 4. The present study showed significantly increased arterial blood pressure, heart rate and baroreflex activity in the early phase of moderate HHcys. In addition, HHcys was associated with alterations of vascular responsiveness to pressor and depressor agents, as well as increased cardiac sympathetic activity. The fact that cardiovascular changes observed in HHcys were reversed after DL-HT washout indicate that moderate HHcys evokes cardiovascular changes.
dc.description35
dc.description8
dc.description949
dc.description956
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationClinical And Experimental Pharmacology And Physiology
dc.relationClin. Exp. Pharmacol. Physiol.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectarterial pressure
dc.subjectbaroreflex
dc.subjectheart rate
dc.subjecthyperhomocysteinemia
dc.subjectvascular reactivity
dc.subjectCoronary-artery-disease
dc.subjectPlasma Total Homocysteine
dc.subjectMedial Prefrontal Cortex
dc.subjectBlood-pressure
dc.subjectEndothelial Dysfunction
dc.subjectHordaland Homocysteine
dc.subjectHypertensive-rats
dc.subjectVascular-disease
dc.subjectNervous-system
dc.subjectFolic-acid
dc.titleHyperhomocysteinaemia-induced cardiovascular changes in rats
dc.typeArtículos de revistas


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