Hydroxyapatite surface solubility and effect on cell adhesion

dc.creatorBertazzo, S
dc.creatorZambuzzi, WF
dc.creatorCampos, DDP
dc.creatorOgeda, TL
dc.creatorFerreira, CV
dc.creatorBertran, CA
dc.date2010
dc.date37073
dc.date2014-11-14T04:58:01Z
dc.date2015-11-26T17:13:19Z
dc.date2014-11-14T04:58:01Z
dc.date2015-11-26T17:13:19Z
dc.date.accessioned2018-03-29T00:01:41Z
dc.date.available2018-03-29T00:01:41Z
dc.identifierColloids And Surfaces B-biointerfaces. Elsevier Science Bv, v. 78, n. 2, n. 177, n. 184, 2010.
dc.identifier0927-7765
dc.identifierWOS:000278167100005
dc.identifier10.1016/j.colsurfb.2010.02.027
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69038
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69038
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69038
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281542
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIn living organisms the biological hydroxyapatite is in constant contact with body fluids, such as blood serum and saliva. Thus, dissolution, solubility and precipitation take place as part of the interaction of this material with biological fluids in tissues. In this work we have obtained the solubility constant for the system formed from aqueous solutions in equilibrium with hydroxyapatite and thus indirectly obtained the composition of the modified hydroxyapatite surface. In order to check the effects of this equilibrium and of the modification that the surface of hydroxyapatite suffers in aqueous solutions, we cultured pre-osteoblasts onto hydroxyapatite discs before and after equilibrium. The results revealed key steps of the mechanism for the bioactivity of hydroxyapatite, which are the solubilization of hydroxyapatite and the equilibrium that is formed on the surface. These processes modify the hydroxyapatite surface, whose composition is changed to a new calcium phosphate compound with the chemical formula of CaHPO(4). A clear description of the transformations that occur on the surface of hydroxyapatite and of the interplay between these transformations and cell activity are two fundamental aspects of processes in which hydroxyapatite takes part, such as bone substitution, bone remodeling, osteoporosis and caries. (C) 2010 Elsevier B.V. All rights reserved.
dc.description78
dc.description2
dc.description177
dc.description184
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationColloids And Surfaces B-biointerfaces
dc.relationColloid Surf. B-Biointerfaces
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectHydroxyapatite
dc.subjectSolubility equilibrium
dc.subjectCell adhesion
dc.subjectBioactivity
dc.subjectCalcium phosphate
dc.subjectSurface modification
dc.subjectMetastable Equilibrium Solubility
dc.subjectCalcium-phosphate
dc.subjectSolid Titration
dc.subjectCarbonated Apatite
dc.subjectDissolution Kinetics
dc.subjectBone
dc.subjectBehavior
dc.subjectPhase
dc.subjectHydroxylapatite
dc.subjectBioceramics
dc.titleHydroxyapatite surface solubility and effect on cell adhesion
dc.typeArtículos de revistas


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