Bioadhesive Films Containing Benzocaine: Correlation Between In Vitro Permeation and In Vivo Local Anesthetic Effect

dc.creatorde Araujo, DR
dc.creatorPadula, C
dc.creatorCereda, CMS
dc.creatorTofoli, GR
dc.creatorBrito, RB
dc.creatorde Paula, E
dc.creatorNicoli, S
dc.creatorSanti, P
dc.date2010
dc.dateAUG
dc.date2014-11-20T03:23:53Z
dc.date2015-11-26T17:13:12Z
dc.date2014-11-20T03:23:53Z
dc.date2015-11-26T17:13:12Z
dc.date.accessioned2018-03-29T00:01:34Z
dc.date.available2018-03-29T00:01:34Z
dc.identifierPharmaceutical Research. Springer/plenum Publishers, v. 27, n. 8, n. 1677, n. 1686, 2010.
dc.identifier0724-8741
dc.identifierWOS:000279506100017
dc.identifier10.1007/s11095-010-0151-5
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55494
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/55494
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55494
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281514
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe aim of this work was to develop anesthetic bioadhesive films containing benzocaine and study their in vitro skin permeation and in vivo performance, in comparison with commercial formulations. Films containing 3% and 5% w/w of benzocaine were prepared and characterized by weight, drug content, thickness and morphology. In vitro permeation assays were performed in vertical diffusion cells using full-thickness pig ear skin as barrier. Intensity and duration of analgesia were evaluated in rats by tail-flick test, and skin histological analysis was carried out. Tail-flick test showed that the duration of benzocaine-induced analgesia was significantly prolonged with the films compared to commercial creams, in agreement with the higher in vitro permeation. Histological analysis of the rat tail skin did not reveal morphological tissue changes nor cell infiltration signs after application of the commercial creams or films. Results from our study indicate that the films developed in this work can be considered as innovative dermal/transdermal therapeutic systems for benzocaine local delivery.
dc.description27
dc.description8
dc.description1677
dc.description1686
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCAPES [0115-070]
dc.descriptionFAPESP [06/00121-9]
dc.languageen
dc.publisherSpringer/plenum Publishers
dc.publisherNew York
dc.publisherEUA
dc.relationPharmaceutical Research
dc.relationPharm. Res.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectbenzocaine
dc.subjectin vitro-in vivo correlation
dc.subjectlocal anestetic
dc.subjectpatch
dc.subjecttransdermal
dc.subjectHairless Guinea-pig
dc.subjectTransdermal Delivery
dc.subjectAminobenzoic Acid
dc.subjectHuman Skin
dc.subjectFormulations
dc.subjectAbsorption
dc.subjectLidocaine
dc.subjectRelease
dc.titleBioadhesive Films Containing Benzocaine: Correlation Between In Vitro Permeation and In Vivo Local Anesthetic Effect
dc.typeArtículos de revistas


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