The expression of PRAME in chronic lymphoproliferative disorders

dc.creatorProto-Siqueira, R
dc.creatorFalcao, RP
dc.creatorde Souza, CA
dc.creatorIsmael, SJ
dc.creatorZago, MA
dc.date2003
dc.dateMAY
dc.date2014-11-20T02:03:49Z
dc.date2015-11-26T17:11:55Z
dc.date2014-11-20T02:03:49Z
dc.date2015-11-26T17:11:55Z
dc.date.accessioned2018-03-29T00:00:23Z
dc.date.available2018-03-29T00:00:23Z
dc.identifierLeukemia Research. Pergamon-elsevier Science Ltd, v. 27, n. 5, n. 393, n. 396, 2003.
dc.identifier0145-2126
dc.identifierWOS:000181622800004
dc.identifier10.1016/S0145-2126(02)00217-5
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73839
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/73839
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73839
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281212
dc.descriptionThe PRAME gene encodes an antigen recognized by autologous T lymphocytes and is expressed in trophoblasts, testis and frequently in human solid cancers and acute leukemias, making it a candidate for immunotherapy and for detecting MRD. We demonstrate expression of PRAME by RT-PCR in the peripheral blood or bone marrow of 26% of 58 patients with CLD (38 cases of CLL, 4 cases of PLL and 16 cases of NHL). Seven out 16 cases of MCL, 2 out 4 of PLL and 6 cases of CLL demonstrated some degree of gene expression. Thus, CLD are among the hematopoietic malignancies for which PRAME may be the target of immunological therapy or used to evaluate MRD. The stronger and more frequent expression of PRAME in MCL is apparently an additional distinguishing feature on this group of lymphoproliferative disorders. (C) 2002 Elsevier Science Ltd. All rights reserved.
dc.description27
dc.description5
dc.description393
dc.description396
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationLeukemia Research
dc.relationLeuk. Res.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectchronic lymphoproliferative disorders
dc.subjectPRAME
dc.subjectimmunotherapy
dc.subjectminimal residual disease
dc.subjectAcute Myeloid-leukemia
dc.subjectAntigen
dc.subjectGene
dc.subjectMelanoma
dc.subjectIdentification
dc.subjectCells
dc.titleThe expression of PRAME in chronic lymphoproliferative disorders
dc.typeArtículos de revistas


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