Stimulation of myelopoiesis in Listeria monocytogenes-infected mice by an aggregated polymer isolated from Aspergillus oryzae

dc.creatorde Melo, A
dc.creatorJusto, GZ
dc.creatorQueiroz, MLD
dc.date2001
dc.dateJAN
dc.date2014-11-17T07:39:45Z
dc.date2015-11-26T17:11:34Z
dc.date2014-11-17T07:39:45Z
dc.date2015-11-26T17:11:34Z
dc.date.accessioned2018-03-29T00:00:03Z
dc.date.available2018-03-29T00:00:03Z
dc.identifierHuman & Experimental Toxicology. Arnold, Hodder Headline Plc, v. 20, n. 1, n. 38, n. 45, 2001.
dc.identifier0144-5952
dc.identifierWOS:000168364100008
dc.identifier10.1191/096032701669333804
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79888
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/79888
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79888
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281128
dc.descriptionIn this work, we investigated the effects of the proteic aggregated polymer of magnesium ammonium phospholinoleate-palmitoleate anhydride (MAPA) isolated from Aspergillus oryzae on the growth and differentiation of bone marrow granulocyte-macrophage progenitor cells (CFU-GM) in Listeria monocytogenes-infected mice. A significant reduction in the CFU-GM number was observed in the initial phase of infection with a sublethal dose of Listeria. Treatment of mice with 0.5, 2.0 and 5.0 mg/kg MAPA for 7 days prior to infection significantly stimulated myelopoiesis in a dose-dependent manner. Moreover, treatment with 0.5 and 5.0 mg/kg MAPA resulted in 30% and 40% cures of mice lethally infected with Listeria, respectively. MAPA added directly to the culture dishes hardly affected colony formation by bone marrow cells, suggesting an indirect effect of this compound on myelopoiesis in vivo. In summary, the data show that MAPA can modulate the CFU-GM generation and antibacterial resistance in listeriosis. As the ability of hematopoietic tissues to produce phagocytes is of particular significance to mediate resistance to Listeria, the promotion of bone marrow CFU-GM by MAPA may contribute to a rapid restoration of phagocyte numbers in infected sites, thus mitigating the course of infection.
dc.description20
dc.description1
dc.description38
dc.description45
dc.languageen
dc.publisherArnold, Hodder Headline Plc
dc.publisherLondon
dc.publisherInglaterra
dc.relationHuman & Experimental Toxicology
dc.relationHum. Exp. Toxicol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectListeria monocytogenes
dc.subjectmyelopoiesis
dc.subjectCFU-GM
dc.subjectMAPA
dc.subjectproteic aggregated polymer of magnesium ammonium phospholinoleate-palmitoleate anhydride
dc.subjectCell-mediated-immunity
dc.subjectInterferon-gamma Production
dc.subjectMarrow Progenitor Cells
dc.subjectTumor-necrosis-factor
dc.subjectNatural-killer-cells
dc.subjectMurine Listeriosis
dc.subjectProstaglandin-e
dc.subjectGenetically Resistant
dc.subjectSusceptible Mice
dc.subjectInflammatory Neutrophils
dc.titleStimulation of myelopoiesis in Listeria monocytogenes-infected mice by an aggregated polymer isolated from Aspergillus oryzae
dc.typeArtículos de revistas


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