Gene expression profiles of erythroid precursors characterise several mechanisms of the action of hydroxycarbamide in sickle cell anaemia

dc.creatorCosta, FC
dc.creatorda Cunha, AF
dc.creatorFattori, A
dc.creatorPeres, TD
dc.creatorCosta, GGL
dc.creatorMachado, TF
dc.creatorde Albuquerque, DM
dc.creatorGambero, S
dc.creatorLanaro, C
dc.creatorSaad, STO
dc.creatorCosta, FF
dc.date2007
dc.dateJAN
dc.date2014-11-13T18:24:34Z
dc.date2015-11-26T17:11:02Z
dc.date2014-11-13T18:24:34Z
dc.date2015-11-26T17:11:02Z
dc.date.accessioned2018-03-28T23:59:35Z
dc.date.available2018-03-28T23:59:35Z
dc.identifierBritish Journal Of Haematology. Blackwell Publishing, v. 136, n. 2, n. 333, n. 342, 2007.
dc.identifier0007-1048
dc.identifierWOS:000243298200021
dc.identifier10.1111/j.1365-2141.2006.06424.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/67841
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/67841
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/67841
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281007
dc.descriptionHydroxycarbamide (HC) (or hydroxyurea) has been reported to increase fetal haemoglobin levels and improve clinical symptoms in sickle cell anaemia (SCA) patients. However, the complete pathway by which HC acts remains unclear. To study the mechanisms involved in the action of HC, global gene expression profiles were obtained from the bone marrow cells of a SCA patient before and after HC treatment using serial analysis of gene expression. In the comparison of both profiles, 147 differentially expressed transcripts were identified. The functional classification of these transcripts revealed a group of gene categories associated with transcriptional and translational regulation, e.g. EGR-1, CENTB1, ARHGAP4 and RIN3, suggesting a possible role for these pathways in the improvement of clinical symptoms of SCA patients. The genes involved in these mechanisms may represent potential tools for the identification of new targets for SCA therapy.
dc.description136
dc.description2
dc.description333
dc.description342
dc.languageen
dc.publisherBlackwell Publishing
dc.publisherOxford
dc.publisherInglaterra
dc.relationBritish Journal Of Haematology
dc.relationBr. J. Haematol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectsickle cell anaemia
dc.subjectfetal haemoglobin
dc.subjecthydroxycarbamide
dc.subjectgene expression
dc.subjectserial analysis of gene expression
dc.subjectSerial Analysis
dc.subjectProtein
dc.subjectHydroxyurea
dc.subjectDisease
dc.subjectIdentification
dc.subjectInterleukin-6
dc.subjectActivation
dc.subjectLeukocytes
dc.subjectPathways
dc.subjectLineage
dc.titleGene expression profiles of erythroid precursors characterise several mechanisms of the action of hydroxycarbamide in sickle cell anaemia
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución