Impact of screening on thrombophilia for patients with venous thrombosis

dc.creatorPaschoa, AF
dc.creatorGuillaumon, AT
dc.date2006
dc.dateMAR
dc.date2014-11-13T17:02:48Z
dc.date2015-11-26T17:10:32Z
dc.date2014-11-13T17:02:48Z
dc.date2015-11-26T17:10:32Z
dc.date.accessioned2018-03-28T23:59:06Z
dc.date.available2018-03-28T23:59:06Z
dc.identifierInternational Angiology. Edizioni Minerva Medica, v. 25, n. 1, n. 52, n. 59, 2006.
dc.identifier0392-9590
dc.identifierWOS:000236826300010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70008
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70008
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280886
dc.descriptionAim. The epidemiologic importance of thrombophilia on venous thromboembolism (VTE) has been extensively studied. We tried to identify the variables that point to the positive test results for thrombophilia and the impact of these results on clinical decisions. Methods. Thrombophilia screening was applied to 84 consecutive patients with VTE. After test results, two independent observers evaluated, in a case by case basis, the indication of a change on prophylaxis or special attention, in order to modify the period of anticoagulant intake or have a higher medical surveillance before risk situations or for the extension of the research to the first degree relatives. Results. Thrombophilia was found in 41.66% (35/84), and in 32.12% (27/84) it involved a genetic cause. The factor V Leiden was found in 15.47%, followed by the natural anticoagulant dysfunction (11.9%). There was no significative difference of thrombophilia frequency between ages, nor a difference of age in the onset of the first thrombotic event between thrombophilic and non-thrombophilic patients. There was a higher prevalence of thrombophilia in patients with superficial thrombophlebitis of spontaneous onset and in cases of recurrence. The change on prophylaxis resulted in 7.14% (6/84) and special attention in 40.47% (34/84). Conclusion. Spontaneous superficial thrombophlebitis, occurrence of VTE related to non surgical causes, and recurrence, were the main findings which suggested thrombophilia. The change of prophylaxis was applied to a small percentage of patients. The special attention for risk situations and the extension of the primary prophylaxis to the asymptomatic family members seems to be the best indication for the laboratorial research on thrombophilia.
dc.description25
dc.description1
dc.description52
dc.description59
dc.languageen
dc.publisherEdizioni Minerva Medica
dc.publisherTurin
dc.publisherItália
dc.relationInternational Angiology
dc.relationInt. Angiol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectthrombophilia
dc.subjectdeep venous thrombosis
dc.subjectfactor V
dc.subjectprothrombin, genetics
dc.subjecthyperhomocysteinemia
dc.subjectvenous thromboembolism, etiology
dc.subjectDeep-vein Thrombosis
dc.subjectOral Anticoagulant-therapy
dc.subjectActivated Protein-c
dc.subjectFactor-v Leiden
dc.subjectRisk-factors
dc.subjectVascular-disease
dc.subjectPulmonary-embolism
dc.subjectProthrombin Gene
dc.subjectClinical Course
dc.subjectThromboembolism
dc.titleImpact of screening on thrombophilia for patients with venous thrombosis
dc.typeArtículos de revistas


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