Obesity Affects Collagen Fibril Diameter and Mechanical Properties of Tendons in Zucker Rats

dc.creatorBiancalana, A
dc.creatorVeloso, LA
dc.creatorGomes, L
dc.date2010
dc.dateJUN
dc.date2014-11-13T15:32:20Z
dc.date2015-11-26T17:10:15Z
dc.date2014-11-13T15:32:20Z
dc.date2015-11-26T17:10:15Z
dc.date.accessioned2018-03-28T23:58:50Z
dc.date.available2018-03-28T23:58:50Z
dc.identifierConnective Tissue Research. Taylor & Francis Ltd, v. 51, n. 3, n. 171, n. 178, 2010.
dc.identifier0300-8207
dc.identifierWOS:000276767800001
dc.identifier10.3109/03008200903191312
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62283
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/62283
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62283
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280819
dc.descriptionObesity is currently considered to be a world epidemic and one of the major public health problems in many countries, whose incidence is increasing at alarming rates. Genetically obese Zucker rats are used as a model of obesity and were employed in the present study. Tendons transmit contractile force from muscles to bone, thus permitting articular movement. The objective of our study was to analyze the ultrastructural, biochemical, and biomechanical alterations that occur in the deep digital flexor tendon of obese Zucker rats compared to lean animals. Ultrastructural analysis showed differences in collagen fibril diameter distribution and mass-average diameter between obese and lean animals. Regarding mechanical parameters, there was a significant difference in maximum displacement and strain. Hydroxyproline content was higher in obese animals. In view of the excess weight and peculiar conditions to which the tendon of obese animals is submitted, we concluded that obesity provokes alterations in the composition and organization of tendon extracellular matrix components. These alterations might be related to organizational and structural modifications in the collagen bundles, influencing the mechanical properties of the tendon and the progression to a pathological state.</.
dc.description51
dc.description3
dc.description171
dc.description178
dc.languageen
dc.publisherTaylor & Francis Ltd
dc.publisherAbingdon
dc.publisherInglaterra
dc.relationConnective Tissue Research
dc.relationConnect. Tissue Res.
dc.rightsfechado
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.sourceWeb of Science
dc.subjectZucker
dc.subjectObesity
dc.subjectTendon
dc.subjectCollagen Fibrils
dc.subjectBiomechanics
dc.subjectHuman Achilles-tendon
dc.subjectGlycosaminoglycan Content
dc.subjectBiomechanical Properties
dc.subjectBiochemical-properties
dc.subjectConnective Tissues
dc.subjectPatellar Tendon
dc.subjectSkeletal-muscle
dc.subjectIii Collagen
dc.subjectAge
dc.subjectExercise
dc.titleObesity Affects Collagen Fibril Diameter and Mechanical Properties of Tendons in Zucker Rats
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución