Is there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?

dc.creatorChagas, CA
dc.creatorEndo, LH
dc.creatordos-Santos, WLC
dc.creatorPinto, GA
dc.creatorSakano, E
dc.creatorBrousset, P
dc.creatorVassallo, J
dc.date2006
dc.dateNOV
dc.date2014-11-19T23:48:42Z
dc.date2015-11-26T17:09:39Z
dc.date2014-11-19T23:48:42Z
dc.date2015-11-26T17:09:39Z
dc.date.accessioned2018-03-28T23:58:17Z
dc.date.available2018-03-28T23:58:17Z
dc.identifierInternational Journal Of Pediatric Otorhinolaryngology. Elsevier Ireland Ltd, v. 70, n. 11, n. 1923, n. 1927, 2006.
dc.identifier0165-5876
dc.identifierWOS:000241932800012
dc.identifier10.1016/j.ijporl.2006.06.020
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60770
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/60770
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60770
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280676
dc.descriptionObjective: Human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV) are human pathogens associated to a number of neoplasms, including tumors of the Waldeyer's ring. Both viruses have been previously detected by in situ methods in tonsils and adenoids from children. HHV-8 was found in 6.8% of the cases and EBV in about one third of the cases. As they belong to the same gamma-herpesvirus subfamily and share some biological characteristics, it is of medical interest to further explore their possible relationship in the Waldeyer's ring, an issue not yet addressed in the specialized literature. The purpose of the present study is to compare the presence of EBV by in situ hybridization (ISH) in tonsils and adenoids from children up to 14 years of age in cases previously shown to be positive and negative for HHV-8. Methods: Paraffin wax-embedded sections consisting of 38 tonsils and two adenoids from 40 patients were analyzed. HHV-8 was detected by ISH, using the T1-1 probe for the viral mRNA. EBV was also detected by ISH, using the EBER probe. Both probes and the detection systems were provided by Novocastra. Results: HHV-8 was detected in 19 tonsils and one adenoid. The other 19 tonsils and one adenoid taken from the HHV-8-negative group were selected by pairing age and gender of patients with the HHV-8-positive group. In both groups EBV was detected in 13 cases and was negative in other 7. Conclusion: Although both viruses are related in many aspects, some biological and epidemiological features differ. This is reflected in the present results, as EBV is similarly detected in the groups negative and positive for HHV-8, favoring different mechanisms of spread. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
dc.description70
dc.description11
dc.description1923
dc.description1927
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationInternational Journal Of Pediatric Otorhinolaryngology
dc.relationInt. J. Pediatr. Otorhinolaryngol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjecthuman herpesvirus 8
dc.subjectEpstein-Barr virus
dc.subjecttonsils
dc.subjectadenoids
dc.subjectin situ hybridization
dc.subjectMulticentric Castlemans-disease
dc.subjectIn-situ Hybridization
dc.subjectKaposis-sarcoma
dc.subjectLymphoid-cells
dc.subjectHerpesvirus
dc.subjectTonsils
dc.subjectLymphocytes
dc.subjectInfection
dc.subjectAdenoids
dc.subjectChildren
dc.titleIs there a relationship between the detection of human herpesvirus 8 and Epstein-Barr virus in Waldeyer's ring tissues?
dc.typeArtículos de revistas


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