Is gastric ulceration different in normal and malnourished rats?

dc.creatorPaula, ACB
dc.creatorGracioso, JS
dc.creatorToma, W
dc.creatorBezerra, R
dc.creatorSaad, MAJ
dc.creatorDe Lucca, IMS
dc.creatorCarneiro, EM
dc.creatorBrito, ARMS
dc.date2005
dc.dateJAN
dc.date2014-11-19T22:40:20Z
dc.date2015-11-26T17:08:58Z
dc.date2014-11-19T22:40:20Z
dc.date2015-11-26T17:08:58Z
dc.date.accessioned2018-03-28T23:57:38Z
dc.date.available2018-03-28T23:57:38Z
dc.identifierBritish Journal Of Nutrition. C A B I Publishing, v. 93, n. 1, n. 47, n. 52, 2005.
dc.identifier0007-1145
dc.identifierWOS:000226919600008
dc.identifier10.1079/BJN20041291
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60745
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/60745
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60745
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280511
dc.descriptionProtein malnutrition can adversely affect all tissues. The aim of the present study was to test the hypothesis that protein deprivation influences gastric ulcer formation, as well as metabolism and organ growth, in rats. In the present study, there was a significant reduction in the body and organ weight of rats fed a low-protein diet (P<0.001). Malnourished rats were less susceptible to ulceration of the gastric mucosa in ethanol and indomethacin models of acute gastric ulcers when compared with rats fed a normoproteic diet (17 % protein). Mucus production and prostaglandin E-2 formation increased in malnourished rats, possibly explaining the lower number of acute ulcers in these animals. Pylorus ligature altered gastric juice composition (increased pH and gastric volume, and decreased total acid concentration) in the animal group fed a low-protein diet compared with the group fed a diet containing 17 % protein (P<0.05). The gastric mucosa was more damaged in malnourished rats than in normal rats evaluated for 14 d after acetic acid injection (P<0.001). Malnourished rats exhibited resistance to acute gastric lesions, owing to an increase in prostaglandin GE(2) release and mucus secretion, which protected their gastric mucosa. This phenomenon was not seen in subchronic gastric ulceration.
dc.descriptiono TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.
dc.description93
dc.description1
dc.description47
dc.description52
dc.languageen
dc.publisherC A B I Publishing
dc.publisherWallingford
dc.publisherInglaterra
dc.relationBritish Journal Of Nutrition
dc.relationBr. J. Nutr.
dc.rightsembargo
dc.sourceWeb of Science
dc.subjectanti-ulcer activity
dc.subjectmalnourishment
dc.subjectcytoprotection
dc.subjectgastric ulcers
dc.subjectInsulin-secretion
dc.subjectGrowth-factors
dc.subjectStress
dc.subjectRestriction
dc.subjectLesions
dc.subjectIslets
dc.subjectDamage
dc.subjectAcid
dc.subjectDiet
dc.titleIs gastric ulceration different in normal and malnourished rats?
dc.typeArtículos de revistas


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