dc.creatorBarao, SC
dc.creatorGiorgio, S
dc.date2003
dc.dateJUL
dc.date2014-08-01T18:30:22Z
dc.date2015-11-26T17:08:24Z
dc.date2014-08-01T18:30:22Z
dc.date2015-11-26T17:08:24Z
dc.date.accessioned2018-03-28T23:57:03Z
dc.date.available2018-03-28T23:57:03Z
dc.identifierChemotherapy. Karger, v. 49, n. 4, n. 159, n. 162, 2003.
dc.identifier0009-3157
dc.identifierWOS:000184639800001
dc.identifier10.1159/000071138
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79904
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79904
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280357
dc.descriptionBackground and Methods: In this study, we investigated the effect of 8-bromoguanosine (8Brguo), an immunostimulatory compound, in a murine model of experimental cutaneous leishmaniasis. Results: The results indicated that treatment by intraperitoneal administration of 8Brguo (150 mg/kg once daily for 1 week and thereafter once weekly for 1 month) diluted in Tween-80 produces an effect similar to that of treatment with the classical antimonial drug, Glucantime, in Leishmania amazonensis-infected CBA/J mice. While complete cure did not occur, animals treated with the nucleoside had small lesions in the infected footpad and delayed surface ulceration. Studies involving examination of serum glutamic pyruvic transaminase activity, concentration of urea, blood pathology and histology of the spleen, kidney and liver showed no apparent toxicity of the nucleoside in treated mice. Conclusion: The protective in vivo effect during murine leishmaniasis as well as the lack of apparent toxicity of 8Brguo as attested by blood/serum pathology and histology from treated mice encourage further studies of C8-substituted guanine ribonucleosides, such as 8Brguo, as new leishmanial drugs and as modifiers of the immunological response to combat infections with intracellular pathogens. Copyright (C) 2003 S. Karger AG, Basel.
dc.description49
dc.description4
dc.description159
dc.description162
dc.languageen
dc.publisherKarger
dc.publisherBasel
dc.publisherSuíça
dc.relationChemotherapy
dc.relationChemotherapy
dc.rightsfechado
dc.rightshttp://www.karger.com/Services/RightsPermissions
dc.sourceWeb of Science
dc.subject8-bromoguanosine
dc.subjectleishmaniasis
dc.subjectLeishmania amazonensis
dc.subjectC8-substituted Guanine Ribonucleosides
dc.subjectMacrophages
dc.subjectActivation
dc.subjectTransport
dc.subjectEnhancement
dc.subjectSurfactants
dc.subjectNucleoside
dc.subjectAntibody
dc.titleEfficacy of 8-bromoguanosine against murine cutaneous leishmaniasis induced with Leishmania amazonensis
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución