Right and left ventricular function and myocardial scarring in adult patients with sickle cell disease: a comprehensive magnetic resonance assessment of hepatic and myocardial iron overload

dc.creatorJunqueira, FP
dc.creatorFernandes, JL
dc.creatorCunha, GM
dc.creatorKubo, TTA
dc.creatorLima, CMAO
dc.creatorLima, DBP
dc.creatorUellendhal, M
dc.creatorSales, SR
dc.creatorCunha, CAS
dc.creatorde Pessoa, VLR
dc.creatorLobo, CLC
dc.creatorMarchiori, E
dc.date2013
dc.dateSEP 19
dc.date2014-08-01T18:30:07Z
dc.date2015-11-26T17:08:23Z
dc.date2014-08-01T18:30:07Z
dc.date2015-11-26T17:08:23Z
dc.date.accessioned2018-03-28T23:57:01Z
dc.date.available2018-03-28T23:57:01Z
dc.identifierJournal Of Cardiovascular Magnetic Resonance. Biomed Central Ltd, v. 15, 2013.
dc.identifier1097-6647
dc.identifierWOS:000324822400001
dc.identifier10.1186/1532-429X-15-83
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79854
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79854
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280351
dc.descriptionBackground: Patients with Sickle cell disease (SCD) who receive regular transfusions are at risk for developing cardiac toxicity from iron overload. The aim of this study was to assess right and left cardiac volumes and function, late gadolinium enhancement (LGE) and iron deposits in patients with SCD using CMR, correlating these values with transfusion burden, ferritin and hemoglobin levels. Methods: Thirty patients with SCD older than 20 years of age were studied in a 1.5 T scanner and compared to age- and sex-matched normal controls. Patients underwent analysis of biventricular volumes and function, LGE and T2* assessment of the liver and heart. Results: When compared to controls, patients with SCD presented higher left ventricular (LV) volumes with decreased ejection fraction (EF) with an increase in stroke volume (SV) and LV hypertrophy. The right ventricle (RV) also presented with a decreased EF and hypertrophy, with an increased end-systolic volume. Although twenty-six patients had increased liver iron concentrations (median liver iron concentration value was 11.83 +/- 9.66 mg/g), only one patient demonstrated an abnormal heart T2* < 20 msec. Only four patients (13%) LGE, with only one patient with an ischemic pattern. Conclusions: Abnormal heart iron levels and myocardial scars are not a common finding in SCD despite increased liver iron overload. The significantly different ventricular function seen in SCD compared to normal suggests the changes in RV and LV function may not be due to the anemia alone. Future studies are necessary to confirm this association.
dc.description15
dc.languageen
dc.publisherBiomed Central Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationJournal Of Cardiovascular Magnetic Resonance
dc.relationJ. Cardiov. Magn. Reson.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectThalassemia Major
dc.subjectPulmonary-hypertension
dc.subjectDiastolic Function
dc.subjectAnemia
dc.subjectHeart
dc.subjectT2-asterisk
dc.subjectCardiomyopathy
dc.subjectDiagnosis
dc.subjectFailure
dc.subjectAbsence
dc.titleRight and left ventricular function and myocardial scarring in adult patients with sickle cell disease: a comprehensive magnetic resonance assessment of hepatic and myocardial iron overload
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución