Effect of Bothrops leucurus venom in chick biventer cervicis preparations

dc.creatorPrianti, ACG
dc.creatorRibeiro, W
dc.creatorLopes-Martins, RAB
dc.creatorLira-Da-Silva, RM
dc.creatorPrado-Franceschi, J
dc.creatorRodrigues-Simioni, L
dc.creatorda Cruz-Hofling, MA
dc.creatorLeite, GB
dc.creatorHyslop, S
dc.creatorCogo, JC
dc.date2003
dc.dateAPR
dc.date2014-11-19T18:40:10Z
dc.date2015-11-26T17:08:08Z
dc.date2014-11-19T18:40:10Z
dc.date2015-11-26T17:08:08Z
dc.date.accessioned2018-03-28T23:56:44Z
dc.date.available2018-03-28T23:56:44Z
dc.identifierToxicon. Pergamon-elsevier Science Ltd, v. 41, n. 5, n. 595, n. 603, 2003.
dc.identifier0041-0101
dc.identifierWOS:000182308500005
dc.identifier10.1016/S0041-0101(03)00002-3
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63772
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/63772
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63772
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280281
dc.descriptionBothrops leucurus is a poorly studied pitviper found in northeastern Brazil. We examined the action of B. leucurus venom (5-100 mug/ml) on contractile responses in chick biventer cervicis preparations. Muscle damage was assessed by quantifying the release of creatine kinase (CK) and by histological analysis. B. leucurus venom dose-dependently inhibited the contractile responses of indirectly stimulated preparations, the maximum inhibition with 100 mug of venom/ml being 74.0 +/- 6.6% (mean +/- SEM) after 120 min. The venom also reduced contractures to exogenous acetylcholine (55 and 110 muM) and K+ (13.4 mM) (85-100% reduction with 100 mug of venom/ml) and increased the release of CK (348 +/- 139 U/ml in controls vs 1260 263 U/ml with 20 [mug of venom/ml after 120 min, p < 0.05). The accompanying morphological changes included multivacuolated, swollen, amorphous fibers and agglutinated myofibrils. These results indicate that B. leucurus venom can adversely affect neuromuscular transmission and produce muscle damage in avian preparations. (C) 2003 Elsevier Science Ltd. All rights reserved.
dc.description41
dc.description5
dc.description595
dc.description603
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationToxicon
dc.relationToxicon
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectBothrops leucurus
dc.subjectmyotoxin
dc.subjectneuromuscular junction
dc.subjectneurotransmission
dc.subjectphospholipase A(2)
dc.subjectvenom
dc.subjectNerve-muscle Preparation
dc.subjectJararacussu Snake-venom
dc.subjectPhospholipase A(2)
dc.subjectMouse
dc.subjectMyotoxins
dc.titleEffect of Bothrops leucurus venom in chick biventer cervicis preparations
dc.typeArtículos de revistas


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