Toward the Reliable Diagnosis of Indeterminate Thyroid Lesions: A HRMAS NMR-Based Metabolomics Case of Study

dc.creatorTorregrossa, L
dc.creatorShintu, L
dc.creatorChandran, JN
dc.creatorTintaru, A
dc.creatorUgolini, C
dc.creatorMagalhaes, A
dc.creatorBasolo, F
dc.creatorMiccoli, P
dc.creatorCaldarelli, S
dc.date2012
dc.dateJUN
dc.date2014-08-01T18:21:40Z
dc.date2015-11-26T17:07:27Z
dc.date2014-08-01T18:21:40Z
dc.date2015-11-26T17:07:27Z
dc.date.accessioned2018-03-28T23:55:59Z
dc.date.available2018-03-28T23:55:59Z
dc.identifierJournal Of Proteome Research. Amer Chemical Soc, v. 11, n. 6, n. 3317, n. 3325, 2012.
dc.identifier1535-3893
dc.identifier1535-3907
dc.identifierWOS:000304682500023
dc.identifier10.1021/pr300105e
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77779
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77779
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280129
dc.descriptionCytological analysis of thyroid nodules detected using ultrasound-guided fine-needle aspiration technique is an efficient method for the diagnosis of well-differenciated tumors such as papillary thyroid carcinoma. However, for between 10 to 30% of all the nodules, the cytological analysis based on fine-needle aspiration biopsies leads to an 'indeterminated' identification. Consequently, a surgical excision is then necessary for a definite histological diagnosis of the lesions, resulting in 85% of the patient with indeterminated nodules undergoing unnecessary surgery since their tumor is finally diagnosed as benign. In this work, we discuss how HRMAS H-1 NMR-based metabolomics could be a complementary tool for the diagnosis of these elusive cases. We first showed that our approach was able to discriminate clearly any types of thyroid lesions from healthy tissues. Then we proceeded to demonstrate that the information produced by H-1 HRMAS NMR spectra differentiate tumors according to their malignancy grade, even when they belong to the 'indeterminate' category. Analysis of the discriminating spectral area in this last case points out toward a possible increase of phenylalanine, taurine, and lactate and a decrease of choline and choline derivatives, myo- and scyllo-inositol in the malignant tumors compared to the benign ones.
dc.description11
dc.description6
dc.description3317
dc.description3325
dc.descriptionUniversita Italo-francese
dc.descriptionANR [ANR-08-BLAN-273, ANR-2011- JS08-014-01]
dc.descriptionRegion PACA [APO-G 2009]
dc.descriptionANR [ANR-08-BLAN-273, ANR-2011- JS08-014-01]
dc.descriptionRegion PACA [APO-G 2009]
dc.languageen
dc.publisherAmer Chemical Soc
dc.publisherWashington
dc.publisherEUA
dc.relationJournal Of Proteome Research
dc.relationJ. Proteome Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectmetabolomics
dc.subjectthyroid cancer
dc.subjectHRMAS NMR
dc.subjectindeterminate
dc.subjectNeedle-aspiration Biopsy
dc.subjectProton-magnetic-resonance
dc.subjectCytological Findings
dc.subjectMutation Analysis
dc.subjectBlood-plasma
dc.subjectCancer
dc.subjectCarcinoma
dc.subjectNodules
dc.subjectSpectroscopy
dc.subjectManagement
dc.titleToward the Reliable Diagnosis of Indeterminate Thyroid Lesions: A HRMAS NMR-Based Metabolomics Case of Study
dc.typeArtículos de revistas


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