Dact Gene Expression Profiles Suggest a Role for This Gene Family in Integrating Wnt and TGF-beta Signaling Pathways During Chicken Limb Development

dc.creatorSensiate, LA
dc.creatorSobreira, DR
dc.creatorDa Veiga, FC
dc.creatorPeterlini, DJ
dc.creatorPedrosa, AV
dc.creatorRirsch, T
dc.creatorJoazeiro, PP
dc.creatorSchubert, FR
dc.creatorCollares-Buzato, CB
dc.creatorXavier-Neto, J
dc.creatorDietrich, S
dc.creatorAlvares, LE
dc.date2014
dc.dateMAR
dc.date2014-08-01T18:27:21Z
dc.date2015-11-26T17:07:05Z
dc.date2014-08-01T18:27:21Z
dc.date2015-11-26T17:07:05Z
dc.date.accessioned2018-03-28T23:55:33Z
dc.date.available2018-03-28T23:55:33Z
dc.identifierDevelopmental Dynamics. Wiley-blackwell, v. 243, n. 3, n. 428, n. 439, 2014.
dc.identifier1058-8388
dc.identifier1097-0177
dc.identifierWOS:000331374000007
dc.identifier10.1002/dvdy.23948
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79155
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79155
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280021
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground:Dact gene family encodes multifunctional proteins that are important modulators of Wnt and TGF- signaling pathways. Given that these pathways coordinate multiple steps of limb development, we investigated the expression pattern of the two chicken Dact genes (Dact1 and Dact2) from early limb bud up to stages when several tissues are differentiating.Results: During early limb development (HH24-HH30) Dact1 and Dact2 were mainly expressed in the cartilaginous rudiments of the appendicular skeleton and perichondrium, presenting expression profiles related, but distinct. At later stages of development (HH31-HH35), the main sites of Dact1 and Dact2 expression were the developing synovial joints. In this context, Dact1 expression was shown to co-localize with regions enriched in the nuclear -catenin protein, such as developing joint capsule and interzone. In contrast, Dact2 expression was restricted to the interzone surrounding the domains of bmpR-1b expression, a TGF- receptor with crucial roles during digit morphogenesis. Additional sites of Dact expression were the developing tendons and digit blastemas.Conclusions: Our data indicate that Dact genes are good candidates to modulate and, possibly, integrate Wnt and TGF- signaling during limb development, bringing new and interesting perspectives about the roles of Dact molecules in limb birth defects and human diseases. Developmental Dynamics 243:428-439, 2014. (c) 2013 Wiley Periodicals, Inc.
dc.description243
dc.description3
dc.description428
dc.description439
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionAFM (The Association Francaise Contre les Myopathies
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2006/05892-3]
dc.languageen
dc.publisherWiley-blackwell
dc.publisherHoboken
dc.publisherEUA
dc.relationDevelopmental Dynamics
dc.relationDev. Dyn.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectDact
dc.subjectDapper
dc.subjectFrodo
dc.subjectchicken embryo
dc.subjectWnt
dc.subjectTGF-
dc.subjectlimb
dc.subjectchondrogenesis
dc.subjectappendicular skeleton
dc.subjectSox9
dc.subjectcartilage
dc.subjectperichondrium
dc.subjectjoint
dc.subjectdigit blastema
dc.subjecttendon
dc.subjectdigit morphogenesis
dc.subjectlimb evolution
dc.subjectVertebrate Limb
dc.subjectCartilage Differentiation
dc.subjectIndian Hedgehog
dc.subjectJoint Formation
dc.subjectMessenger-rnas
dc.subjectNeural Crest
dc.subjectCell-death
dc.subjectChondrogenesis
dc.subjectCatenin
dc.subjectEmbryo
dc.titleDact Gene Expression Profiles Suggest a Role for This Gene Family in Integrating Wnt and TGF-beta Signaling Pathways During Chicken Limb Development
dc.typeArtículos de revistas


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