Intrinsic laryngeal muscles are spared from myonecrosis in the mdx mouse model of duchenne muscular dystrophy

dc.creatorMarques, MJ
dc.creatorFerretti, R
dc.creatorVomero, VU
dc.creatorMinatel, E
dc.creatorNeto, HS
dc.date2007
dc.dateMAR
dc.date2014-11-17T07:23:55Z
dc.date2015-11-26T17:07:04Z
dc.date2014-11-17T07:23:55Z
dc.date2015-11-26T17:07:04Z
dc.date.accessioned2018-03-28T23:55:32Z
dc.date.available2018-03-28T23:55:32Z
dc.identifierMuscle & Nerve. John Wiley & Sons Inc, v. 35, n. 3, n. 349, n. 353, 2007.
dc.identifier0148-639X
dc.identifierWOS:000244723600009
dc.identifier10.1002/mus.20697
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60564
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/60564
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60564
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280017
dc.descriptionIntrinsic laryngeal muscles share many anatomical and physiological properties with extraocular muscles, which are unaffected in both Duchenne muscular dystrophy and mdx mice. We hypothesized that intrinsic laryngeal muscles are spared from myonecrosis in mdx mice and may serve as an additional tool to understand the mechanisms of muscle sparing in dystrophinopathy. Intrinsic laryngeal muscles and tibialis anterior (TA) muscle of adult and aged mdxand control C57BI/10 mice were investigated. The percentage of central nucleated fibers, as a sign of muscle fibers that had undergone injury and regeneration, and myofiber labeling with Evans blue dye, as a marker of myofiber damage, were studied. Except for the cricothyroid muscle, none of the intrinsic. laryngeal muscles from adult and old mdx mice showed signs of myofiber damage or Evans blue dye labeling, and all appeared to be normal. Central nucleation was readily visible in the TA of the same mdx mice. A significant increase in the percentage of central nucleated fibers was observed in adult cricothyroid muscle compared to the other intrinsic laryngeal muscles, which worsened with age. Thus, we have shown that the intrinsic laryngeal muscles are spared from the lack of dystrophin and may serve as a useful model to study the mechanisms of muscle sparing in dystrophinopathy.
dc.description35
dc.description3
dc.description349
dc.description353
dc.languageen
dc.publisherJohn Wiley & Sons Inc
dc.publisherHoboken
dc.publisherEUA
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectaging
dc.subjectdystrophin
dc.subjectintrinsic laryngeal muscles
dc.subjectmdx mouse
dc.subjectmuscle regeneration
dc.subjectAge-related-changes
dc.subjectExtraocular-muscles
dc.subjectCalcium Homeostasis
dc.subjectGene-expression
dc.subjectFiber Types
dc.subjectMyofibers
dc.subjectMyopathy
dc.subjectMarker
dc.subjectMice
dc.titleIntrinsic laryngeal muscles are spared from myonecrosis in the mdx mouse model of duchenne muscular dystrophy
dc.typeArtículos de revistas


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