Greater accrual damage in late-onset systemic lupus erythematosus: a long-term follow-up study

dc.creatorAppenzeller, S
dc.creatorPereira, DA
dc.creatorCostallat, LTL
dc.date2008
dc.date2014-07-30T17:51:21Z
dc.date2015-11-26T17:06:51Z
dc.date2014-07-30T17:51:21Z
dc.date2015-11-26T17:06:51Z
dc.date.accessioned2018-03-28T23:55:21Z
dc.date.available2018-03-28T23:55:21Z
dc.identifierLupus. Sage Publications Ltd, v. 17, n. 11, n. 1023, n. 1028, 2008.
dc.identifier0961-2033
dc.identifierWOS:000260720400010
dc.identifier10.1177/0961203308089695
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68453
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68453
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279973
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe main objective of this study was to evaluate the clinical differences and the pattern and extent of organ damage in late-onset systemic lupus erythematosus (SLE). A nested case-control study was performed from patients with SLE followed in the Rheumatology Unit of the State University of Campinas between 1974 and 2005. Patients who developed SLE after the age of 49 were considered late-onset SLE. SLE patients with age <49 years, matched for sex, ethnicity, disease duration and organ damage at Study entry were randomly chosen to compose the control group. Baseline and cumulative clinical manifestations, laboratory data, SLE disease activity index (SLEDAI), Systemic Lupus International Collaborating Clinics/American College of Rheumatology-damage index (SDI) and mortality were compared between groups. At diagnosis and follow-up, late-onset group had lower SLEDAI scores when compared with Younger age onset. Clinically, they presented less frequently arthritis (P = 0.0002) and malar rash (P = 0.02) and more frequently Raynaud's phenomenon (P = 0.002) and arterial hypertension (P = 0.02) when compared with young onset at diagnosis. Late-onset SLE received lower total corticosteroid dose (P < 0.001) and less frequently cyclophosphamide (P = 0.01). During the study period, late-onset SLE had always lower SLEDAI scores (P = 0.001). At study endpoint, late-onset SLE patients had significantly higher SDI scores (P = 0.001) and a higher mortality rate when compared with younger onset group (P < 0.01). In conclusion, late-onset SLE is milder on presentation and during course of disease, but patients have more organ damage and a higher rate of mortality than young onset SLE. Patients with late onset should be followed with close monitoring and early identification of complications is mandatory in this subgroup of patients with SLE. Lupus (2008) 17, 1023-1028.
dc.description17
dc.description11
dc.description1023
dc.description1028
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherSage Publications Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationLupus
dc.relationLupus
dc.rightsfechado
dc.rightshttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.sourceWeb of Science
dc.subjectcumulative damage
dc.subjectlate-onset survival
dc.subjectSLE
dc.subjectOlder Age Group
dc.subject3 Ethnic-groups
dc.subjectDisease-activity
dc.subjectClinical-features
dc.subjectSouthern Chinese
dc.subjectManifestations
dc.subjectCohort
dc.subjectIndex
dc.subjectPrognosis
dc.subjectCriteria
dc.titleGreater accrual damage in late-onset systemic lupus erythematosus: a long-term follow-up study
dc.typeArtículos de revistas


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