Gray and white matter imbalance - Typical structural abnormality underlying classic autism?

dc.creatorBonilha, L
dc.creatorCendes, F
dc.creatorRorden, C
dc.creatorEckert, M
dc.creatorDalgalarrondo, P
dc.creatorLi, LM
dc.creatorSteiner, CE
dc.date2008
dc.dateJUN
dc.date2014-07-30T17:51:21Z
dc.date2015-11-26T17:06:50Z
dc.date2014-07-30T17:51:21Z
dc.date2015-11-26T17:06:50Z
dc.date.accessioned2018-03-28T23:55:18Z
dc.date.available2018-03-28T23:55:18Z
dc.identifierBrain & Development. Elsevier Science Bv, v. 30, n. 6, n. 396, n. 401, 2008.
dc.identifier0387-7604
dc.identifierWOS:000256065900004
dc.identifier10.1016/j.braindev.2007.11.006
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68449
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68449
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279962
dc.descriptionRecent evidence supports increased cortical activity and impaired brain connectivity in autism, but the structural correlates of these abnormalities are not yet defined. We performed a voxel based morphometry analysis of brain MRI from patients with autism selected from a group of 103 subjects with pervasive developmental disorders. Twelve male patients with mean age of 12.4 +/- 4 years were compared with 16 matched controls. Patients with autism exhibited increase in gray matter in medial and dorsolateral frontal areas, in the lateral and medial parts of the temporal lobes, in the parietal lobes, cerebellum and claustrum. Patients also showed decrease in frontal, parietal, temporal and occipital white matter. The combination of enlarged cortex and reduced white matter is possibly the structural basis of some symptoms of classic autism. (C) 2007 Elsevier B.V. All rights reserved.
dc.description30
dc.description6
dc.description396
dc.description401
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationBrain & Development
dc.relationBrain Dev.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectautism
dc.subjectbrain structure
dc.subjectgray matter
dc.subjectwhite matter
dc.subjectconnectivity
dc.subjectVoxel-based Morphometry
dc.subjectSpectrum Disorders
dc.subjectFrontal-cortex
dc.subjectBrain
dc.subjectMri
dc.subjectPrevalence
dc.subjectLife
dc.titleGray and white matter imbalance - Typical structural abnormality underlying classic autism?
dc.typeArtículos de revistas


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