Fenvalerate, A Pyrethroid Insecticide, Adversely Affects Sperm Production and Storage in Male Rats

dc.creatorArena, AC
dc.creatorFernandez, CDB
dc.creatorPorto, EM
dc.creatorBissacot, DZ
dc.creatorPereira, OCM
dc.creatorKempinas, WG
dc.date2008
dc.date2014-07-30T17:34:47Z
dc.date2015-11-26T17:06:47Z
dc.date2014-07-30T17:34:47Z
dc.date2015-11-26T17:06:47Z
dc.date.accessioned2018-03-28T23:55:15Z
dc.date.available2018-03-28T23:55:15Z
dc.identifierJournal Of Toxicology And Environmental Health-part A-current Issues. Taylor & Francis Inc, v. 71, n. 23, n. 1550, n. 1558, 2008.
dc.identifier1528-7394
dc.identifier1087-2620
dc.identifierWOS:000260085900005
dc.identifier10.1080/15287390802392024
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66855
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66855
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279951
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe aim of this study was to investigate the potential estrogenic activity of fenvalerate by examining reproductive and fertility capabilities in Wistar rats. Adult male animals were treated for 30 d with 20 or 40 mg/kg/d fenvalerate or corn oil (vehicle) by oral gavage. Further, a possible estrogenic activity of fenvalerate (0.4, 1, 4, 8, or 40 mg/kg) was tested after a 3-d treatment of immature female rats using the uterotrophic assay. Exposure to the higher dose of fenvalerate was toxic to testis and epididymis as shown by a decrease in the absolute weights and sperm counts in both organs. Although the sperm counts were reduced, the fertility and sexual behavior were similar in control rats and rats treated with 40 mg/kg pesticide. Fenvalerate did not exert estrogenic activity in vivo at the tested doses. Data suggest that fenvalerate treatment in this study failed to compromise fertility, possibly due to enhanced reproductive capacity in rodents compared to humans.
dc.description71
dc.description23
dc.description1550
dc.description1558
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [02/09455-6, 04/08627-3]
dc.languageen
dc.publisherTaylor & Francis Inc
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationJournal Of Toxicology And Environmental Health-part A-current Issues
dc.relationJ. Toxicol. Env. Health Part A
dc.rightsfechado
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.sourceWeb of Science
dc.subjectPesticide Factory-workers
dc.subjectSprague-dawley Rats
dc.subjectProgesterone Production
dc.subjectSynthetic Pyrethroids
dc.subjectUterotrophic Assay
dc.subjectEndocrine System
dc.subjectEpididymal Sperm
dc.subjectSexual-behavior
dc.subjectGranulosa-cells
dc.subjectDairy-cows
dc.titleFenvalerate, A Pyrethroid Insecticide, Adversely Affects Sperm Production and Storage in Male Rats
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución