Quantitative Spot-Test Analysis of Metformin in Pharmaceutical Preparations Using Ultraviolet-Visible Diffuse Reflectance Spectroscopy

dc.creatorTubino, M
dc.creatorBianchessi, LF
dc.creatorVila, MMDC
dc.date2010
dc.dateJAN
dc.date2014-11-19T14:38:03Z
dc.date2015-11-26T17:06:44Z
dc.date2014-11-19T14:38:03Z
dc.date2015-11-26T17:06:44Z
dc.date.accessioned2018-03-28T23:55:12Z
dc.date.available2018-03-28T23:55:12Z
dc.identifierAnalytical Sciences. Japan Soc Analytical Chemistry, v. 26, n. 1, n. 121, n. 124, 2010.
dc.identifier0910-6340
dc.identifierWOS:000273653500020
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58652
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/58652
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58652
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279936
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionA quantitative spot-test for the determination of metformin in pharmaceutical preparations using diffuse UV-visible reflectance is reported. The procedure is quite simple, involving in the formation of a metformin-nickel(II) complex on a glass filter membrane with a later measurement of the reflectance in the spectrophotometer using an integration sphere. The analytical results obtained with commercial products were statistically compared with those resulting from a method recommended by JP and by USP, where complete agreement was observed. The average RSD is 2.5% and the detection (0.009 mol L(-1)) and the quantitation (0.03 cool L(-1)) limits are quite adequate for pharmaceutical analysis.
dc.description26
dc.description1
dc.description121
dc.description124
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherJapan Soc Analytical Chemistry
dc.publisherTokyo
dc.publisherJapão
dc.relationAnalytical Sciences
dc.relationAnal. Sci.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectPhase Liquid-chromatography
dc.subjectMulticomponent Dosage Forms
dc.subjectReflectometric Method
dc.subjectPure Form
dc.subjectFormulations
dc.subjectHydrochloride
dc.subjectSpectrophotometry
dc.subjectRosiglitazone
dc.subjectSpectrometry
dc.subjectGlipizide
dc.titleQuantitative Spot-Test Analysis of Metformin in Pharmaceutical Preparations Using Ultraviolet-Visible Diffuse Reflectance Spectroscopy
dc.typeArtículos de revistas


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