Myocardial function after fetal cardiac bypass in an ovine model

dc.creatorDuffy, JY
dc.creatorPetrucci, O
dc.creatorBaker, RS
dc.creatorLam, CT
dc.creatorReed, CA
dc.creatorEverman, DJ
dc.creatorEghtesady, P
dc.date2011
dc.dateAPR
dc.date2014-08-01T18:39:37Z
dc.date2015-11-26T17:06:40Z
dc.date2014-08-01T18:39:37Z
dc.date2015-11-26T17:06:40Z
dc.date.accessioned2018-03-28T23:55:09Z
dc.date.available2018-03-28T23:55:09Z
dc.identifierJournal Of Thoracic And Cardiovascular Surgery. Mosby-elsevier, v. 141, n. 4, n. 961, n. U373, 2011.
dc.identifier0022-5223
dc.identifierWOS:000288541300018
dc.identifier10.1016/j.jtcvs.2010.08.031
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81938
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81938
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279921
dc.descriptionObjective: Fetal cardiac surgery might improve the prognosis of certain complex congenital heart defects that have significant associated mortality and morbidity in utero or after birth. An important step in translating fetal cardiac surgery is identifying potential mechanisms leading to myocardial dysfunction after bypass. The hypothesis was that fetal cardiac bypass results in myocardial dysfunction, possibly because of perturbation of calcium cycling and contractile proteins. Methods: Midterm sheep fetuses (n = 6) underwent 30 minutes of cardiac bypass and 120 minutes of monitoring after bypass. Sonomicrometric and pressure catheters inserted in the left and right ventricles measured myocardial function. Cardiac contractile and calcium cycling proteins, along with calpain, were analyzed by means of immunoblotting. Results: Preload recruitable stroke work (slope of the regression line) was reduced at 120 minutes after bypass (right ventricle: baseline vs 120 minutes after bypass, 38.6 +/- 6.8 vs 20.4 +/- 4.8 [P = .01]; left ventricle: 37 +/- 7.3 vs 20.6 +/- 3.9, respectively [P = .01]). Tau (in milliseconds), a measure of diastolic relaxation, was increased in both ventricles (right ventricle: baseline vs 120 minutes after bypass, 32.7 +/- 4.5 vs 67.8 +/- 9.4 [P < .01]); left ventricle: 26.1 +/- 3.2 vs 63.2 +/- 11.2, respectively [P = .01]). Cardiac output was lower and end-diastolic pressures were higher in the right ventricle, but not in the left ventricle, after bypass compared with baseline values. Right ventricular troponin I was degraded by increased calpain activity, and protein levels of sarco(endo) plasmic reticulum calcium ATPase were reduced in both ventricles. Conclusions: Fetal cardiac bypass was associated with myocardial dysfunction and disruption of calcium cycling and contractile proteins. Minimizing myocardial dysfunction after cardiac bypass is important for successful fetal surgery to repair complex congenital heart defects. (J Thorac Cardiovasc Surg 2011;141:961-8)
dc.description141
dc.description4
dc.description961
dc.descriptionU373
dc.languageen
dc.publisherMosby-elsevier
dc.publisherNew York
dc.publisherEUA
dc.relationJournal Of Thoracic And Cardiovascular Surgery
dc.relationJ. Thorac. Cardiovasc. Surg.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectLeft-heart Syndrome
dc.subjectTroponin-i
dc.subjectCardiopulmonary Bypass
dc.subjectDysfunction
dc.subjectSurgery
dc.subjectVolume
dc.subjectLevel
dc.subjectSheep
dc.titleMyocardial function after fetal cardiac bypass in an ovine model
dc.typeArtículos de revistas


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