Angiogenic and lymphangiogenic microvessel density in recurrent pleomorphic adenoma

dc.creatorSoares, AB
dc.creatorde Araujo, VC
dc.creatorJuliano, PB
dc.creatorAltemani, A
dc.date2009
dc.dateSEP
dc.date2014-08-01T18:20:34Z
dc.date2015-11-26T17:05:48Z
dc.date2014-08-01T18:20:34Z
dc.date2015-11-26T17:05:48Z
dc.date.accessioned2018-03-28T23:54:11Z
dc.date.available2018-03-28T23:54:11Z
dc.identifierJournal Of Oral Pathology & Medicine. Wiley-blackwell Publishing, Inc, v. 38, n. 8, n. 623, n. 629, 2009.
dc.identifier0904-2512
dc.identifierWOS:000269503300002
dc.identifier10.1111/j.1600-0714.2009.00794.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77429
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77429
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279678
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: Recurrent pleomorphic adenoma (RPA) is an uncommon and challenging disease. The aim of this study was to determine if there is a difference between RPA and the pleomorphic adenoma (PA) without recurrence related to tumor blood and lymphatic vascularization. Moreover, we compared the microvessel density (MVD) between cell-rich areas (predominance of epithelial cells) and cell-poor areas (predominance of myxoid and chondroid areas) of the stroma of PA and RPA. In addition, immunohistochemical staining for the Ki-67 antigen was conducted simultaneously to evaluate cell proliferation in PA and RPA. Methods: A total of 19 cases of PA and 24 cases of RPA, blood, and lymphatic vessels were analyzed by immunohistochemical technique using the antibodies CD34, CD105, D2-40, and Ki-67. Results: Comparing no recurrent with recurrent tumor, no significant difference was found in terms of lymphatic vessel density, MVD, and proliferation index. When MVD and proliferation index were compared with different areas in cellular composition (cell-rich and cell-poor areas), there was a significant difference in PA, as well as in RPA. Conclusion: This study shows that although RPA presents more aggressive clinical behavior than PA, there is no difference between tumor blood and lymphatic vascularization, suggesting that there is no correlation between vascularity and risk of recurrence. Furthermore, vascularized stroma in PA, as well as RPA, depends on the proportion of the cellular composition.
dc.description38
dc.description8
dc.description623
dc.description629
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [07/55206-1, 08/50167-0]
dc.languageen
dc.publisherWiley-blackwell Publishing, Inc
dc.publisherMalden
dc.publisherEUA
dc.relationJournal Of Oral Pathology & Medicine
dc.relationJ. Oral Pathol. Med.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectblood vessel
dc.subjectlymph vessel
dc.subjectpleomorphic adenoma
dc.subjectrecurrence
dc.subjectvascular density
dc.subjectEndothelial Growth-factor
dc.subjectFactor Vegf Expression
dc.subjectParotid-gland
dc.subjectMicrovascular Density
dc.subjectTumor Angiogenesis
dc.subjectBreast-carcinoma
dc.subjectSalivary-gland
dc.subjectProgression
dc.subjectSystem
dc.titleAngiogenic and lymphangiogenic microvessel density in recurrent pleomorphic adenoma
dc.typeArtículos de revistas


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