Androgen Deprivation Therapy And Morbid Obesity: Do They Share Cardiovascular Risk Through Metabolic Syndrome?

dc.creatorCleffi, S
dc.creatorNeto, AS
dc.creatorReis, LO
dc.creatorMaia, P
dc.creatorFonseca, F
dc.creatorWroclawski, ML
dc.creatorNeves, M
dc.creatorPompeo, ACL
dc.creatorDel Giglio, A
dc.creatorFaria, EF
dc.creatorTobias-Machado, M
dc.date2011
dc.dateMAY
dc.date2014-08-01T18:20:33Z
dc.date2015-11-26T17:05:40Z
dc.date2014-08-01T18:20:33Z
dc.date2015-11-26T17:05:40Z
dc.date.accessioned2018-03-28T23:54:02Z
dc.date.available2018-03-28T23:54:02Z
dc.identifierActas Urologicas Espanolas. Ene Ediciones Sl, v. 35, n. 5, n. 259, n. 265, 2011.
dc.identifier0210-4806
dc.identifierWOS:000290512200002
dc.identifier10.1016/j.acuro.2011.01.011
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77416
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77416
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279645
dc.descriptionBackground: Although the use of androgen deprivation therapy (ADT) has resulted in improved survival in men with advanced prostate cancer, the resulting hypogonadism is associated with profound adverse effects comparable to those found in morbid obesity, being cardiovascular risk among the most lethal. Objectives: Evaluate metabolic syndrome, metabolic abnormalities and cardiovascular risk in patients with prostate cancer under ADT, not under ADT and morbid obese men. Methods: This is a cross-sectional study that involves 79 men presenting prostate cancer, of whom 54 under ADT and 25 not under ADT and 91 morbidly obese patients paired by sex and age. To define metabolic syndrome, we used the International Diabetes Federation (IDF) criteria. Metabolic abnormalities, metabolic markers and Framingham score to predict the ten year coronary heart disease risk were compared among patients under ADT, not under ADT and morbid obese. Results: Patients under ADT presented significantly greater occurrence of diabetes and central obesity and higher levels of total cholesterol and low density lipoprotein (LDL) compared to eugonadal men. The mean cardiovascular risk was significantly higher in patients under ADT (39.97 +/- 12.53% vs. 26.09 +/- 14.80%; p = 0.021). Morbidly obese subjects had increased ten year coronary heart disease risk; comparable to patients under ADT (p = 0.054). Conclusion: This study suggests that patients under ADT show higher prevalence of metabolic abnormalities and cardiovascular risk similar to those found in morbidly obese subjects. It is possible that both processes share cardiovascular risk through metabolic syndrome. (C) 2010 AEU. Published by Elsevier Espana, S.L. All rights reserved.
dc.description35
dc.description5
dc.description259
dc.description265
dc.languagees
dc.publisherEne Ediciones Sl
dc.publisherMadrid
dc.publisherEspanha
dc.relationActas Urologicas Espanolas
dc.relationActas Urol. Esp.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectProstate cancer
dc.subjectMetabolic syndrome
dc.subjectCardiovascular risk
dc.subjectMorbid obesity
dc.subjectAndrogen deprivation
dc.subjectLocalized Prostate-cancer
dc.subjectInsulin-resistance
dc.subjectRadical Prostatectomy
dc.subjectMen
dc.subjectTestosterone
dc.subjectHypogonadism
dc.subjectDisease
dc.subjectDysfunction
dc.subjectCarcinoma
dc.subjectProfile
dc.titleAndrogen Deprivation Therapy And Morbid Obesity: Do They Share Cardiovascular Risk Through Metabolic Syndrome?
dc.typeArtículos de revistas


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