Release properties of chemical and enzymatic crosslinked gelatin-gum Arabic microparticles containing a fluorescent probe plus vetiver essential oil

dc.creatorPrata, AS
dc.creatorZanin, MHA
dc.creatorRe, MI
dc.creatorGrosso, CRF
dc.date2008
dc.dateDEC 1
dc.date2014-11-19T11:32:00Z
dc.date2015-11-26T17:05:33Z
dc.date2014-11-19T11:32:00Z
dc.date2015-11-26T17:05:33Z
dc.date.accessioned2018-03-28T23:53:55Z
dc.date.available2018-03-28T23:53:55Z
dc.identifierColloids And Surfaces B-biointerfaces. Elsevier Science Bv, v. 67, n. 2, n. 171, n. 178, 2008.
dc.identifier0927-7765
dc.identifierWOS:000261665600004
dc.identifier10.1016/j.colsurfb.2008.08.014
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70850
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70850
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70850
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279613
dc.descriptionOil-containing gelatin-gum Arabic microparticles were prepared by complex coacervation followed by crosslinking with glutaraldehyde or transglutaminase. A fluorescent mixture, khusimyl dansylate (KD) as the fluorescent compound mixed to the vetiver essential oil, was used as oil model. The effect of the type of crosslinking of the coacervated gelatin-gum Arabic membrane, the physical state of microparticles, wet or freeze-dried and the type of release media, aqueous with surfactants, Sodium Dodecyl Sulphate (sds) or Tween 80 (tw) and anhydrous ethanol as organic media on the release rate of the KD from the microparticles, was experimentally investigated. It was shown that the oil was dispersed uniformly throughout the microparticles and the chemical crosslinked microparticles were more resistant to swelling, presenting smaller sizes after hydration. Also the crosslinking effect, transglutaminase or glutaraldehyde, Could be confirmed by the integrity of the crosslinked gelatin-gum Arabic microparticles after incubation in the aqueous sds media, compared to complete dissolution of the uncrosslinked microparticles in this media. The cumulative fluorescent KD release from the gelatin-gum Arabic microparticles decreased in the following order of dissolution media: anhydrous ethanol > tw > sds and the wet microparticles have shown a faster KID release than freeze-dried ones. A mathematical model was used to estimate the diffusion coefficient (D). The chemically crosslinked gelatin-gum Arabic microparticles ensured a pronounced retard effect in the KD diffusion, presenting a D varying from 0.02 to 0.6 x 10(-11) cm(2)/s, mainly in all aqueous media, against D varying from 1.05 to 13.9 x 10(-11) cm(2)/s from the enzymatic crosslinked microparticles. (C) 2008 Elsevier B.V. All rights reserved.
dc.description67
dc.description2
dc.description171
dc.description178
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationColloids And Surfaces B-biointerfaces
dc.relationColloid Surf. B-Biointerfaces
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectMicroparticles
dc.subjectComplex coacervation
dc.subjectControlled release
dc.subjectEnzymatic crosslinking
dc.subjectChemical crosslinking
dc.subjectSodium Dodecyl-sulfate
dc.subjectIn-vitro
dc.subjectComplex Coacervation
dc.subjectSustained-release
dc.subjectBurst Release
dc.subjectMicrocapsules
dc.subjectMicroencapsulation
dc.subjectLinking
dc.subjectDrug
dc.subjectEncapsulation
dc.titleRelease properties of chemical and enzymatic crosslinked gelatin-gum Arabic microparticles containing a fluorescent probe plus vetiver essential oil
dc.typeArtículos de revistas


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